KEGG   DRUG: D01128Help
Entry
D01128                      Drug                                   

Name
Ramatroban (JAN/INN);
Baynas (TN)
Formula
C21H21FN2O4S
Exact mass
416.1206
Mol weight
416.4658
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-asthmatic [thromboxane receptor antagonist];
Anti-inflammatory [nonantihistaminic]
Remark
Therapeutic category: 
Target
thromboxane A2 (TXA2) receptor antagonist [HSA:6915] [KO:K04264];
prostaglandin D2 receptor antagonist [HSA:5729] [KO:K04332]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Eicosanoids
Eicosanoid receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01128  Ramatroban (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    prostaglandin D2 receptor
     Ramatroban
      D01128  Ramatroban (JAN/INN)
   Thromboxane
    thromboxane A2 (TXA2) receptor
     Ramatroban
      D01128  Ramatroban (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
116649-85-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1b C    29.1759  -17.4458
            2   C1b C    30.5733  -17.4458
            3   N4y N    28.4773  -18.6560
            4   C6a C    31.2719  -16.2357
            5   C1y C    24.7942  -20.6074
            6   C1x C    24.7937  -19.2163
            7   C1x C    25.9979  -18.5205
            8   C8y C    27.2029  -19.2155
            9   C8y C    27.2034  -20.6064
            10  C1x C    25.9990  -21.3023
            11  C8x C    29.3958  -22.1157
            12  C8x C    30.7989  -19.6999
            13  C8x C    31.4942  -20.9119
            14  C8x C    30.7957  -22.1180
            15  C8y C    29.4053  -19.6940
            16  C8y C    28.7034  -20.8972
            17  N1b N    23.5843  -21.3064
            18  S4a S    22.3740  -20.6082
            19  C8y C    21.1640  -21.3074
            20  C8x C    19.9601  -20.6089
            21  C8x C    18.7502  -21.3081
            22  C8y C    18.7507  -22.7054
            23  C8x C    19.9611  -23.4036
            24  C8x C    21.1709  -22.7044
            25  X   F    17.5409  -23.4044
            26  O6a O    32.6693  -16.2357
            27  O6a O    30.5733  -15.0255
            28  O3c O    21.1616  -19.9082
            29  O3c O    23.5864  -19.9082
BOND        32
            1     5   6 1
            2     6   7 1
            3    15  16 1
            4    16   9 1
            5     8   3 1
            6     3  15 1
            7     7   8 1
            8     5  17 1 #Down
            9     8   9 2
            10   17  18 1
            11    9  10 1
            12   18  19 1
            13   10   5 1
            14    1   2 1
            15    2   4 1
            16    1   3 1
            17   11  16 2
            18   15  12 2
            19   19  20 2
            20   20  21 1
            21   21  22 2
            22   22  23 1
            23   23  24 2
            24   24  19 1
            25   12  13 1
            26   22  25 1
            27   13  14 2
            28    4  26 1
            29   14  11 1
            30    4  27 2
            31   18  28 2
            32   18  29 2

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