KEGG   DRUG: LafutidineHelp
Entry
D01131                      Drug                                   

Name
Lafutidine (JP17/INN);
Protecadin (TN)
Formula
C22H29N3O4S
Exact mass
431.1879
Mol weight
431.5484
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Gastrointestinal agent
 DG01481  Histamine receptor H2 antagonist
Unclassified
  DG01481  Histamine receptor H2 antagonist
Remark
Therapeutic category: 
ATC code: 
Activity
Anti-ulcerative, H2 receptor antagonist
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA08 Lafutidine
      D01131  Lafutidine (JP17/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D01131  Lafutidine (JP17/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor
     Lafutidine
      D01131  Lafutidine (JP17/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01131  Lafutidine
  D01131  Lafutidine tablets
Gastrointestinal agents [br08371.html]
 Antiulcer agent
  D01131
BRITE hierarchy
Other DBs
CAS: 
118288-08-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1x C    11.2700  -29.7500
            2   C1x C    11.2700  -31.1500
            3   C1x C    12.4600  -31.8500
            4   N1y N    13.7200  -31.1500
            5   C1x C    13.7200  -29.7500
            6   C1x C    12.4600  -29.0500
            7   C1b C    14.9100  -31.8500
            8   C8y C    16.1000  -31.1500
            9   C8x C    17.2900  -31.8500
            10  C8y C    18.5500  -31.1500
            11  N5x N    18.5500  -29.7500
            12  C8x C    17.3600  -29.0500
            13  C8x C    16.1000  -29.7500
            14  O2a O    19.7400  -31.8500
            15  C1b C    20.9300  -31.1500
            16  C2b C    22.1200  -31.8500
            17  C2b C    23.5200  -31.8500
            18  C1b C    24.7100  -31.1500
            19  N1b N    25.9000  -31.8500
            20  C5a C    27.0900  -31.1500
            21  C1b C    28.2800  -31.8500
            22  S4a S    29.4700  -31.1500
            23  C1b C    30.6600  -31.8500
            24  C8y C    31.8500  -31.1500
            25  O3c O    29.4700  -29.7500
            26  O5a O    27.0900  -29.7500
            27  C8x C    32.2700  -29.8200
            28  O2x O    32.9700  -31.9900
            29  C8x C    34.0900  -31.1500
            30  C8x C    33.6700  -29.8200
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   10  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 2
            19   18  19 1
            20   18  17 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   22  25 2
            27   20  26 2
            28   27  24 2
            29   24  28 1
            30   28  29 1
            31   29  30 2
            32   27  30 1

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