KEGG   DRUG: PimobendanHelp
Entry
D01133                      Drug                                   

Name
Pimobendan (JAN/USAN/INN);
Acardi (TN)
Formula
C19H18N4O2
Exact mass
334.143
Mol weight
334.3718
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01758  Pimobendan type cardiotonic
 DG01507  Phosphodiesterase III inhibitor
  DG01758  Pimobendan type cardiotonic
Remark
Therapeutic category: 
Activity
Cardiotonic, Phosphodiesterase inhibitor
Comment
Calcium sensitizer
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296]
  Pathway
Purine metabolism
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D01133  Pimobendan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   phosphodiesterase (PDE) III
    Pimobendan
     D01133  Pimobendan (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
74150-27-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C    22.8226  -19.5081
            2   C8y C    21.6142  -18.8080
            3   C8x C    21.6142  -17.4079
            4   C8x C    22.8226  -16.7079
            5   C8y C    24.0381  -18.8080
            6   C8y C    24.0413  -17.4074
            7   N4x N    25.3744  -16.9777
            8   C8y C    26.1948  -18.1127
            9   N5x N    25.3691  -19.2439
            10  C2y C    20.4011  -19.5071
            11  C8y C    27.5949  -18.1160
            12  C8x C    28.2973  -16.9061
            13  C8x C    29.6975  -16.9095
            14  C8y C    30.3946  -18.1236
            15  C8x C    29.6917  -19.3345
            16  C8x C    28.2916  -19.3313
            17  O2a O    31.7948  -18.1270
            18  C1a C    32.4919  -19.3411
            19  N2x N    20.4027  -20.9004
            20  N1x N    19.1896  -21.5996
            21  C5x C    17.9775  -20.8987
            22  C1x C    17.9785  -19.4986
            23  C1y C    19.1916  -18.7994
            24  O5x O    16.7644  -21.5978
            25  C1a C    19.1962  -17.3993
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     5   6 2
            5    11  12 1
            6    12  13 2
            7    13  14 1
            8    14  15 2
            9    15  16 1
            10   16  11 2
            11    6   7 1
            12   14  17 1
            13    7   8 1
            14   17  18 1
            15    8   9 2
            16    9   5 1
            17    4   6 1
            18    2  10 1
            19   10  19 2
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  10 1
            25    8  11 1
            26   21  24 2
            27    5   1 1
            28   23  25 1

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