KEGG   DRUG: D01133Help
Entry
D01133                      Drug                                   

Name
Pimobendan (JAN/USAN/INN);
Acardi (TN)
Formula
C19H18N4O2
Exact mass
334.143
Mol weight
334.3718
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiotonic
Remark
Therapeutic category: 
Drug group: 
Comment
Calcium sensitizer
Target
phosphodiesterase (PDE) III inhibitor [HSA:5139 5140] [KO:K13296]
  Pathway
hsa00230  Purine metabolism
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D01133  Pimobendan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   phosphodiesterase (PDE) III
    Pimobendan
     D01133  Pimobendan (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
74150-27-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C    22.8226  -19.5081
            2   C8y C    21.6142  -18.8080
            3   C8x C    21.6142  -17.4079
            4   C8x C    22.8226  -16.7079
            5   C8y C    24.0381  -18.8080
            6   C8y C    24.0413  -17.4074
            7   N4x N    25.3744  -16.9777
            8   C8y C    26.1948  -18.1127
            9   N5x N    25.3691  -19.2439
            10  C2y C    20.4011  -19.5071
            11  C8y C    27.5949  -18.1160
            12  C8x C    28.2973  -16.9061
            13  C8x C    29.6975  -16.9095
            14  C8y C    30.3946  -18.1236
            15  C8x C    29.6917  -19.3345
            16  C8x C    28.2916  -19.3313
            17  O2a O    31.7948  -18.1270
            18  C1a C    32.4919  -19.3411
            19  N2x N    20.4027  -20.9004
            20  N1x N    19.1896  -21.5996
            21  C5x C    17.9775  -20.8987
            22  C1x C    17.9785  -19.4986
            23  C1y C    19.1916  -18.7994
            24  O5x O    16.7644  -21.5978
            25  C1a C    19.1962  -17.3993
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     5   6 2
            5    11  12 1
            6    12  13 2
            7    13  14 1
            8    14  15 2
            9    15  16 1
            10   16  11 2
            11    6   7 1
            12   14  17 1
            13    7   8 1
            14   17  18 1
            15    8   9 2
            16    9   5 1
            17    4   6 1
            18    2  10 1
            19   10  19 2
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  10 1
            25    8  11 1
            26   21  24 2
            27    5   1 1
            28   23  25 1

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