KEGG   DRUG: AzelnidipineHelp
Entry
D01145                      Drug                                   

Name
Azelnidipine (JP17/INN);
Azelnidipine tablets (JP17);
Calblock (TN)
Formula
C33H34N4O6
Exact mass
582.2478
Mol weight
582.6463
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
Activity
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01145  Azelnidipine (JP17/INN); Azelnidipine tablets (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Azelnidipine
      D01145  Azelnidipine (JP17/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Azelnidipine
    D01145  Azelnidipine (JP17/INN)
  CYP3A
   Azelnidipine
    D01145  Azelnidipine (JP17/INN)
 Transporter inhibitors
  ABCB1
   Azelnidipine
    D01145  Azelnidipine (JP17/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01145  Azelnidipine
  D01145  Azelnidipine tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01145
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01145
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01145
BRITE hierarchy
Other DBs
CAS: 
123524-52-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        43
            1   C1c C    30.2706  -18.7179
            2   C8y C    30.2638  -20.1079
            3   C8y C    31.4780  -18.0290
            4   N1y N    29.0705  -18.0169
            5   C1y C    27.6806  -16.6268
            6   C1x C    27.6806  -18.0169
            7   C1x C    29.0705  -16.6268
            8   C2y C    21.6713  -14.5489
            9   C2y C    21.6713  -15.9390
            10  C1y C    22.8779  -16.6340
            11  C2y C    24.0775  -15.9390
            12  C2y C    24.0775  -14.5489
            13  N1x N    22.8779  -13.8540
            14  C8y C    22.8798  -18.0240
            15  C8x C    21.6831  -18.7156
            16  C8x C    21.6848  -20.1055
            17  C8x C    22.8894  -20.7990
            18  C8y C    24.0924  -20.1025
            19  C8x C    24.0905  -18.7125
            20  C7a C    20.4708  -16.6340
            21  O7a O    19.2704  -15.9390
            22  C1c C    18.0699  -16.6340
            23  C1a C    16.8695  -15.9390
            24  O6a O    20.4708  -18.0240
            25  C1a C    18.0699  -18.0240
            26  C1a C    20.4680  -13.8533
            27  N1a N    25.2818  -13.8549
            28  C7a C    25.2726  -16.6268
            29  O7a O    26.4731  -15.9319
            30  C8x C    32.6697  -18.7334
            31  C8x C    33.8770  -18.0445
            32  C8x C    33.8841  -16.6545
            33  C8x C    32.6838  -15.9535
            34  C8x C    31.4764  -16.6424
            35  N2b N    25.2968  -20.7959 #+
            36  O6a O    25.2743  -18.0169
            37  O3a O    25.2987  -22.1860 #-
            38  O3a O    26.8471  -19.6828
            39  C8x C    29.0380  -20.8078
            40  C8x C    29.0314  -22.2078
            41  C8x C    30.2404  -22.9136
            42  C8x C    31.4662  -22.2137
            43  C8x C    31.4728  -20.8137
BOND        47
            1    20  21 1
            2     8   9 2
            3    21  22 1
            4     9  10 1
            5    22  23 1
            6    10  11 1
            7    20  24 2
            8    11  12 2
            9    22  25 1
            10   12  13 1
            11    8  26 1
            12   13   8 1
            13   12  27 1
            14    4   7 1
            15   11  28 1
            16   10  14 1
            17   28  29 1
            18   29   5 1
            19    7   5 1
            20    1   4 1
            21    1   3 1
            22    1   2 1
            23    3  30 2
            24   30  31 1
            25   31  32 2
            26   32  33 1
            27   33  34 2
            28   34   3 1
            29   14  15 2
            30   15  16 1
            31   16  17 2
            32   17  18 1
            33   18  19 2
            34   19  14 1
            35   18  35 1
            36    5   6 1
            37   28  36 2
            38    9  20 1
            39   35  37 1
            40    6   4 1
            41   35  38 2
            42    2  39 2
            43   39  40 1
            44   40  41 2
            45   41  42 1
            46   42  43 2
            47    2  43 1

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