| Entry |
|
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| Name |
Aripiprazole (JAN/USAN/INN);
Abilify (TN)
|
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| Product |
ABILIFY (Bryant Ranch Prepack), ABILIFY (Bryant Ranch Prepack), ABILIFY (Bryant Ranch Prepack), ABILIFY (Cardinal Health), ABILIFY (H.J. Harkins Company), ABILIFY (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical Surgical & Supply DBA Quality Care Products LLC), ABILIFY MAINTENA (OTSUKA PHARMACEUTICAL), ABILIFY (Otsuka America Pharmaceutical), ABILIFY (PD-Rx Pharmaceuticals), ABILIFY (Physicians Total Care), ABILIFY (Rebel Distributors Corp.), ABILIFY (STAT RX USA LLC) |
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| Generic |
|
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| Formula |
C23H27Cl2N3O2
|
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| Exact mass |
447.148
|
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| Mol weight |
448.3854
|
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| Structure |
     |
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| Activity |
Antipsychotic: Antischizophrenic
|
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
Dopamine system stabilizer (Dopamine-serotonin system stabilizer) (DSS)
|
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| Target |
dopamine D2-receptor agonist/antagonist [HSA: 1813] [KO: K04145]; 5-HT2A-receptor antagonist [HSA: 3356] [KO: K04157]; 5-HT1A-receptor agonist/antagonist [HSA: 3350] [KO: K04153] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
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| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
 |
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| Structure map |
| Dopamine receptor agonists/antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01164 Aripiprazole (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AX Other antipsychotics
N05AX12 Aripiprazole
D01164 Aripiprazole (JAN/USAN/INN)
USP drug classification [BR:br08302]
Antidepressants
Antidepressants, Other
Augmentation Agents
Aripiprazole
D01164 Aripiprazole (JAN/USAN/INN)
Antipsychotics
2nd Generation/Atypical
Aripiprazole
D01164 Aripiprazole (JAN/USAN/INN)
Bipolar Agents
Bipolar Agents, Other
Aripiprazole
D01164 Aripiprazole (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
dopamine D2-receptor [HSA:1813] [KO:K04145]
Aripiprazole [ATC:N05AX12]
D01164 Aripiprazole (JAN/USAN/INN)
Serotonin
5-HT1A-receptor [HSA:3350] [KO:K04153]
Aripiprazole [ATC:N05AX12]
D01164 Aripiprazole (JAN/USAN/INN)
5-HT2A-receptor [HSA:3356] [KO:K04157]
Aripiprazole [ATC:N05AX12]
D01164 Aripiprazole (JAN/USAN/INN)
 |
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| Other DBs |
CAS: 129722-12-9 PubChem: DrugBank: LigandBox: |
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| KCF data |
ATOM 30
1 C8y C 21.1093 -20.1077
2 C8x C 21.1093 -18.7072
3 C8x C 19.8936 -18.0069
4 C8x C 19.8936 -20.8080
5 C8y C 18.6849 -20.1077
6 C8y C 18.6910 -18.7072
7 C1x C 16.2652 -18.6969
8 C5x C 16.2592 -20.0974
9 N1x N 17.4691 -20.8027
10 O5x O 15.0434 -20.7924
11 O2a O 22.3219 -20.8085
12 C1b C 23.5352 -20.1089
13 C1b C 24.7476 -20.8099
14 C1b C 25.9609 -20.1101
15 C1b C 27.1735 -20.8110
16 N1y N 28.3868 -20.1115
17 C1x C 29.5955 -20.8116
18 C1x C 30.8088 -20.1120
19 N1y N 30.8094 -18.7115
20 C1x C 29.5970 -18.0105
21 C1x C 28.4537 -18.7103
22 C8y C 32.0227 -18.0119
23 C8y C 33.2328 -18.7123
24 C8y C 34.4460 -18.0127
25 C8x C 34.4467 -16.6123
26 C8x C 33.2341 -15.9114
27 C8x C 32.0208 -16.6111
28 X Cl 33.2316 -20.1128
29 X Cl 35.6585 -18.7137
30 C1x C 17.4783 -18.0066
BOND 33
1 5 4 2
2 14 15 1
3 5 6 1
4 15 16 1
5 30 7 1
6 7 8 1
7 8 9 1
8 9 5 1
9 4 1 1
10 16 17 1
11 17 18 1
12 18 19 1
13 19 20 1
14 20 21 1
15 21 16 1
16 8 10 2
17 19 22 1
18 1 11 1
19 1 2 2
20 11 12 1
21 2 3 1
22 22 23 2
23 23 24 1
24 24 25 2
25 25 26 1
26 26 27 2
27 27 22 1
28 12 13 1
29 23 28 1
30 3 6 2
31 24 29 1
32 13 14 1
33 6 30 1
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