KEGG   DRUG: CilnidipineHelp
Entry
D01173                      Drug                                   

Name
Cilnidipine (JP17/INN);
Atelec (TN)
Formula
C27H28N2O7
Exact mass
492.1897
Mol weight
492.5204
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
  DG01572  Calcium channel N type blocker
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
CACNA1-N [HSA:774] [KO:K04849]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA14 Cilnidipine
      D01173  Cilnidipine (JP17/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01173  Cilnidipine (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel N type
     Cilnidipine
      D01173  Cilnidipine (JP17/INN)
    calcium channel L type
     Cilnidipine
      D01173  Cilnidipine (JP17/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C19
   Cilnidipine
    D01173  Cilnidipine (JP17/INN)
  CYP2D6
   Cilnidipine
    D01173  Cilnidipine (JP17/INN)
  CYP3A4
   Cilnidipine
    D01173  Cilnidipine (JP17/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01173  Cilnidipine
  D01173  Cilnidipine tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01173
BRITE hierarchy
Other DBs
CAS: 
132203-70-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C2y C    24.6047  -12.8785
            2   C2y C    24.6047  -14.2686
            3   C1y C    25.8115  -14.9635
            4   C2y C    27.0112  -14.2686
            5   C2y C    27.0112  -12.8785
            6   N1x N    25.8115  -12.1834
            7   C8y C    25.8132  -16.3537
            8   C8x C    24.6163  -17.0454
            9   C8x C    24.6181  -18.4355
            10  C8x C    25.8229  -19.1291
            11  C8y C    27.0259  -18.4325
            12  C8x C    27.0242  -17.0424
            13  N2b N    28.2307  -19.1260 #+
            14  C7a C    28.2157  -14.9626
            15  O6a O    28.2167  -16.3527
            16  O7a O    29.4188  -14.2667
            17  C1b C    30.6233  -14.9609
            18  C2b C    31.8267  -14.2648
            19  C2b C    33.2121  -14.2614
            20  C1a C    28.2157  -12.1842
            21  C1a C    23.4012  -12.1827
            22  C7a C    23.4012  -14.9641
            23  O7a O    22.1970  -14.2697
            24  O6a O    23.4019  -16.3542
            25  C1b C    20.9934  -14.9654
            26  C1b C    19.7892  -14.2709
            27  O2a O    18.5858  -14.9666
            28  O3a O    29.7117  -18.1514
            29  O3a O    28.2324  -20.5161 #-
            30  C8y C    34.4127  -13.5593
            31  C8x C    34.4749  -12.1687
            32  C1a C    17.3815  -14.2723
            33  C8x C    35.5926  -14.3129
            34  C8x C    36.9051  -13.6678
            35  C8x C    36.8974  -12.2772
            36  C8x C    35.7174  -11.5236
BOND        38
            1     3   4 1
            2    17  18 1
            3     4   5 2
            4    18  19 2
            5     5   6 1
            6     5  20 1
            7     7   8 2
            8     1  21 1
            9     8   9 1
            10    2  22 1
            11    9  10 2
            12   22  23 1
            13   10  11 1
            14   22  24 2
            15   11  12 2
            16   23  25 1
            17   12   7 1
            18   25  26 1
            19    6   1 1
            20   26  27 1
            21   11  13 1
            22   13  28 2
            23   13  29 1
            24    4  14 1
            25   19  30 1
            26    3   7 1
            27   14  15 2
            28    1   2 2
            29   14  16 1
            30    2   3 1
            31   31  30 1
            32   16  17 1
            33   27  32 1
            34   30  33 2
            35   33  34 1
            36   34  35 2
            37   35  36 1
            38   31  36 2

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