KEGG   DRUG: D01176Help
Entry
D01176                      Drug                                   

Name
Blonanserin (JAN/INN);
AD 5423
Formula
C23H30FN3
Exact mass
367.2424
Mol weight
367.5028
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotics
Remark
Therapeutic category: 
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01176  Blonanserin (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Blonanserin
      D01176  Blonanserin (JAN/INN)
   Serotonin
    5-HT2A-receptor
     Blonanserin
      D01176  Blonanserin (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Blonanserin
    D01176  Blonanserin (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
132810-10-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C    18.6615  -14.9275
            2   C8y C    18.6615  -16.3259
            3   C8y C    19.8755  -17.0251
            4   C8x C    21.0824  -16.3259
            5   C8y C    21.0824  -14.9275
            6   N5x N    19.8755  -14.2283
            7   C1x C    17.6737  -17.3297
            8   C1x C    16.2651  -17.3297
            9   C1x C    17.6737  -13.9339
            10  C1x C    15.2715  -16.3301
            11  C1x C    16.2651  -13.9339
            12  C1x C    15.2715  -14.9275
            13  N1y N    22.2940  -14.2292
            14  C8y C    19.8772  -18.4235
            15  C8x C    18.6681  -19.1227
            16  C8x C    18.6698  -20.5211
            17  C8y C    19.8818  -21.2187
            18  C8x C    21.0920  -20.5180
            19  C8x C    21.0902  -19.1196
            20  X   F    19.8836  -22.6171
            21  C1x C    23.5010  -14.9299
            22  C1x C    24.7126  -14.2315
            23  N1y N    24.7136  -12.8331
            24  C1x C    23.5032  -12.1331
            25  C1x C    22.2916  -12.8313
            26  C1b C    25.9252  -12.1348
            27  C1a C    27.1358  -12.8350
BOND        30
            1     5  13 1
            2     3  14 1
            3     1   2 2
            4     2   3 1
            5     3   4 2
            6     4   5 1
            7     5   6 2
            8    14  15 2
            9    15  16 1
            10   16  17 2
            11   17  18 1
            12   18  19 2
            13   19  14 1
            14    2   7 1
            15   17  20 1
            16    7   8 1
            17    1   9 1
            18    8  10 1
            19    9  11 1
            20   10  12 1
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  13 1
            27   11  12 1
            28   23  26 1
            29    6   1 1
            30   26  27 1

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