KEGG   DRUG: D01182Help
Entry
D01182                      Drug                                   

Name
Alprenolol hydrochloride (JP16/USAN);
Regletin (TN)
Formula
C15H23NO2. HCl
Exact mass
285.1496
Mol weight
285.8096
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA01 Alprenolol
      D01182  Alprenolol hydrochloride (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D01182  Alprenolol hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Alprenolol
      D01182  Alprenolol hydrochloride (JP16/USAN)
    beta2-adrenergic receptor
     Alprenolol
      D01182  Alprenolol hydrochloride (JP16/USAN)
    beta3-adrenergic receptor
     Alprenolol
      D01182  Alprenolol hydrochloride (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Alprenolol
    D01182  Alprenolol hydrochloride (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01182  Alprenolol hydrochloride
BRITE hierarchy
Other DBs
CAS: 
13707-88-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C1b C    12.2500   -5.1800
            2   C1c C    13.4400   -5.8800
            3   C1b C    14.6300   -5.1800
            4   N1b N    15.8200   -5.8800
            5   C1c C    17.0800   -5.1800
            6   C1a C    18.2700   -5.8800
            7   O2a O    10.9900   -5.8800
            8   O1a O    13.4400   -7.2800
            9   C1a C    17.0800   -3.7800
            10  C8y C    10.9900   -7.2800
            11  C8y C     9.7776   -7.9800
            12  C8x C     9.7776   -9.3800
            13  C8x C    10.9900  -10.0800
            14  C8x C    12.2024   -9.3800
            15  C8x C    12.2024   -7.9800
            16  C1b C     8.5821   -7.2896
            17  C2b C     7.3947   -7.9751
            18  C2a C     7.3947   -9.3751
            19  X   Cl   16.8000   -9.1700
BOND        18
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     2   8 1
            6     7   1 1
            7     5   9 1
            8     1   2 1
            9     7  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   10  15 1
            16   11  16 1
            17   16  17 1
            18   17  18 2

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