| Entry |
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| Name |
Olmesartan medoxomil (JAN/USAN);
Benicar (TN);
Olmetec (TN)
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| Product |
|
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| Formula |
C29H30N6O6
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| Exact mass |
558.2227
|
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| Mol weight |
558.5851
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| Structure |
     |
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| Activity |
Treatment of hypertension [novel angiotensin (Ang II) antagonist]
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| Remark |
Therapeutic category: ATC code: |
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| Target |
angiotensin II receptor type 1 (AT1) antagonist [HSA: 185] [KO: K04166] |
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| Pathway |
|
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| Metabolism |
Transporter: SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234], ABCC2 [HSA: 1244]
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| Interaction |
|
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| Structure map |
| Angiotensin receptor and endothelin receptor antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01204 Olmesartan medoxomil (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
C09CA Angiotensin II antagonists, plain
C09CA08 Olmesartan medoxomil
D01204 Olmesartan medoxomil (JAN/USAN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Angiotensin II Receptor Antagonists
Olmesartan
D01204 Olmesartan medoxomil (JAN/USAN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Angiotensin
angiotensin II stimulates angiotensin subtype 1 (AT1) receptor [HSA:185] [KO:K04166]
Olmesartan medoxomil [ATC:C09CA08]
D01204 Olmesartan medoxomil (JAN/USAN)
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| Other DBs |
CAS: 144689-63-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 41
1 C1a C 37.1157 -18.9063
2 C8y C 36.4167 -20.1172
3 C8y C 35.0273 -20.1154
4 O7x O 34.6625 -21.4576
5 C8y C 35.8267 -22.2192
6 O7x O 36.9105 -21.3475
7 C1d C 37.1245 -16.2033
8 C8y C 36.4254 -14.9925
9 C7a C 34.3282 -16.2033
10 O7a O 35.0273 -17.4142
11 C8y C 35.0273 -14.9925
12 C1b C 33.3849 -12.9584
13 C8y C 32.1706 -13.6513
14 N4y N 34.5923 -13.6636
15 N5x N 36.8607 -13.6636
16 C8y C 35.7264 -12.8387
17 C8x C 30.9657 -12.9436
18 C8x C 29.7513 -13.6365
19 C8y C 29.7441 -15.0346
20 C8x C 30.9515 -15.7398
21 C8x C 32.1659 -15.0469
22 C8y C 28.5299 -15.7275
23 C8y C 27.3266 -15.0171
24 C8x C 26.1123 -15.7102
25 C8x C 26.1051 -17.1083
26 C8x C 27.3125 -17.8134
27 C8x C 28.5269 -17.1204
28 C8y C 27.2672 -13.6190
29 N5x N 28.4069 -12.8028
30 N5x N 27.9847 -11.4699
31 N5x N 26.5867 -11.4598
32 N4x N 26.1447 -12.7860
33 C1b C 34.3282 -18.6250
34 O6a O 35.8253 -23.6158
35 O6a O 32.9301 -16.2033
36 C1b C 35.7264 -11.4406
37 C1b C 34.5155 -10.7415
38 C1a C 33.3046 -11.4406
39 C1a C 37.8245 -17.4158
40 C1a C 38.3324 -15.5058
41 O1a O 35.9087 -16.6254
BOND 45
1 17 18 1
2 18 19 2
3 19 20 1
4 20 21 2
5 21 13 1
6 9 11 1
7 19 22 1
8 2 3 2
9 12 13 1
10 1 2 1
11 12 14 1
12 22 23 2
13 23 24 1
14 24 25 2
15 25 26 1
16 26 27 2
17 27 22 1
18 7 8 1
19 23 28 1
20 3 4 1
21 8 15 1
22 15 16 2
23 16 14 1
24 28 29 2
25 29 30 1
26 30 31 2
27 31 32 1
28 32 28 1
29 14 11 1
30 10 33 1
31 33 3 1
32 11 8 2
33 4 5 1
34 5 34 2
35 5 6 1
36 9 35 2
37 9 10 1
38 16 36 1
39 6 2 1
40 36 37 1
41 13 17 2
42 37 38 1
43 7 39 1
44 7 40 1
45 7 41 1
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