KEGG   DRUG: D01228Help
Entry
D01228                      Drug                                   

Name
Distigmine bromide (JP16/INN);
Ubretid (TN)
Formula
C22H32N4O4. 2Br
Exact mass
574.079
Mol weight
576.3219
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinesterase [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA03 Distigmine
      D01228  Distigmine bromide (JP16/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1231  Quaternary ammoniums
     D01228  Distigmine bromide (JP16/INN)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1312  Miotic agents
     D01228  Distigmine bromide (JP16/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01228  Distigmine bromide
  D01228  Distigmine bromide tablets
BRITE hierarchy
Other DBs
CAS: 
15876-67-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   X   Br   10.8112  -13.6523 #-
            2   X   Br   32.7804  -20.1826 #-
            3   C8y C    29.7353  -17.3380
            4   C8x C    29.7284  -18.7366
            5   N5y N    30.9361  -19.4420 #+
            6   C8x C    32.1507  -18.7488
            7   C8x C    32.1578  -17.3503
            8   C8x C    30.9502  -16.6449
            9   C8y C    14.0147  -16.7005
            10  O7a O    15.2248  -17.3903
            11  C8x C    14.0147  -15.2917
            12  C8x C    12.7989  -17.3962
            13  C7a C    16.4406  -16.6947
            14  N5y N    12.7989  -14.5844 #+
            15  C8x C    11.5772  -16.7005
            16  N1c N    17.6566  -17.3845
            17  O6a O    16.4348  -15.2800
            18  C8x C    11.5772  -15.2917
            19  C1a C    12.8047  -13.1816
            20  C1b C    18.8667  -16.6771
            21  C1a C    17.6566  -18.7875
            22  C1b C    20.0796  -17.3662
            23  C1b C    21.2803  -16.6669
            24  C1b C    22.4953  -17.3592
            25  C1b C    23.6960  -16.6599
            26  C1b C    24.9110  -17.3521
            27  N1c N    26.1117  -16.6529
            28  C7a C    27.3267  -17.3450
            29  O7a O    28.5275  -16.6458
            30  O6a O    27.3196  -18.7436
            31  C1a C    30.9686  -20.8345
            32  C1a C    26.1051  -15.2323
BOND        31
            1     9  11 1
            2     9  12 2
            3    10  13 1
            4    11  14 2
            5    12  15 1
            6    13  16 1
            7    13  17 2
            8    14  18 1
            9    14  19 1
            10   16  20 1
            11   16  21 1
            12   15  18 2
            13    4   5 2
            14   20  22 1
            15    5   6 1
            16   22  23 1
            17    6   7 2
            18   23  24 1
            19    7   8 1
            20   24  25 1
            21    8   3 2
            22   25  26 1
            23   26  27 1
            24   27  28 1
            25   28  29 1
            26   29   3 1
            27    3   4 1
            28   28  30 2
            29    9  10 1
            30    5  31 1
            31   27  32 1

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