KEGG   DRUG: D01242Help
Entry
D01242                      Drug                                   

Name
Promethazine teoclate (JAN/INN);
Avomine (TN)
Formula
C17H20N2S. C7H7ClN4O2
Exact mass
498.1605
Mol weight
499.0282
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antipsychotics
Phenothiazines
Hypnotics
Histamine H1 receptor antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D01242  Promethazine teoclate (JAN/INN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D01242  Promethazine teoclate (JAN/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D01242  Promethazine teoclate (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Promethazine
      D01242  Promethazine teoclate (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Promethazine
    D01242  Promethazine teoclate (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
17693-51-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C8y C    30.2443  -17.6964
            2   C8y C    30.2506  -19.0899
            3   N5x N    28.9273  -19.5264
            4   C8y C    28.1034  -18.4026
            5   N4x N    28.9172  -17.2718
            6   C8y C    32.6628  -19.0943
            7   N4y N    31.4535  -19.7945
            8   C8y C    31.4501  -16.9997
            9   N4y N    32.6611  -17.6969
            10  C1a C    33.8790  -16.9939
            11  O5x O    31.4605  -15.5937
            12  O5x O    33.8790  -19.7875
            13  C1a C    31.4605  -21.1947
            14  X   Cl   26.7081  -18.4013
            15  C8y C    21.7358  -19.8545
            16  C8y C    21.7987  -21.2547
            17  C8x C    22.9378  -21.9610
            18  C8x C    24.2240  -21.2670
            19  C8x C    24.2309  -19.8667
            20  C8x C    22.9520  -19.1604
            21  C8y C    19.3172  -19.8474
            22  C8y C    19.3100  -21.2476
            23  S2x S    20.5191  -21.9539
            24  N1y N    20.5334  -19.1533
            25  C8x C    16.8986  -19.8474
            26  C8x C    16.8986  -21.2476
            27  C8x C    18.1141  -21.9477
            28  C8x C    18.1141  -19.1473
            29  C1b C    20.5193  -17.7470
            30  C1c C    21.7287  -17.0398
            31  C1a C    22.9379  -17.7398
            32  N1c N    21.7217  -15.6395
            33  C1a C    22.9310  -14.9324
            34  C1a C    20.5053  -14.9394
BOND        37
            1     7   2 1
            2     1   8 1
            3     8   9 1
            4     9   6 1
            5     3   4 2
            6     9  10 1
            7     4   5 1
            8     8  11 2
            9     5   1 1
            10    6  12 2
            11    7  13 1
            12    4  14 1
            13    1   2 2
            14    2   3 1
            15    6   7 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  15 1
            22   21  22 2
            23   22  23 1
            24   23  16 1
            25   15  24 1
            26   24  21 1
            27   25  26 1
            28   26  27 2
            29   27  22 1
            30   21  28 1
            31   28  25 2
            32   24  29 1
            33   29  30 1
            34   30  31 1
            35   30  32 1
            36   32  33 1
            37   32  34 1

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