KEGG   DRUG: D01245Help
Entry
D01245                      Drug                                   

Name
Bromazepam (JP16/USAN/INN);
Lectopam (TN)
Formula
C14H10BrN3O
Exact mass
315.0007
Mol weight
316.1527
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA08 Bromazepam
      D01245  Bromazepam (JP16/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01245  Bromazepam (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Bromazepam
      D01245  Bromazepam (JP16/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Bromazepam
    D01245  Bromazepam (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01245  Bromazepam
BRITE hierarchy
Other DBs
CAS: 
1812-30-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C2y C    24.7372  -14.4900
            2   C8y C    24.0263  -13.5768
            3   C8y C    24.7372  -15.9464
            4   N2x N    26.1244  -14.4900
            5   C8y C    24.0032  -12.2763
            6   N5x N    23.4772  -16.6690
            7   C8x C    26.0087  -16.6690
            8   C1x C    26.8527  -13.7617
            9   N1x N    25.3961  -11.4382
            10  C8x C    23.4772  -18.1370
            11  C8x C    26.0087  -18.1370
            12  C5x C    26.8527  -12.1722
            13  C8x C    24.7431  -18.8653
            14  C8x C    22.7785  -11.5979
            15  C8x C    21.5787  -12.3194
            16  C8y C    21.5318  -13.6199
            17  C8x C    22.8265  -14.2982
            18  X   Br   20.3297  -14.3182
            19  O5x O    28.0608  -11.4278
BOND        21
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    7  11 2
            11    8  12 1
            12   10  13 2
            13    9  12 1
            14   11  13 1
            15    5  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19    2  17 1
            20   16  18 1
            21   12  19 2

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