KEGG   DRUG: D01245Help
Entry
D01245                      Drug                                   

Name
Bromazepam (JP16/USAN/INN);
Lectopam (TN)
Formula
C14H10BrN3O
Exact mass
315.0007
Mol weight
316.1527
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA08 Bromazepam
      D01245  Bromazepam (JP16/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01245  Bromazepam (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Bromazepam
      D01245  Bromazepam (JP16/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Bromazepam
    D01245  Bromazepam (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01245  Bromazepam
BRITE hierarchy
Other DBs
CAS: 
1812-30-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    22.4658  -15.1408
            2   N1x N    23.7321  -14.5533
            3   C5x C    24.9889  -15.1713
            4   C1x C    25.2855  -16.5295
            5   C8y C    22.1408  -16.5117
            6   N2x N    24.4084  -17.6240
            7   C2y C    23.0070  -17.6120
            8   C8y C    22.3836  -18.8818
            9   N5x N    21.0001  -18.8853
            10  C8x C    20.3041  -20.1001
            11  C8x C    21.0080  -21.3102
            12  C8x C    22.3927  -21.3057
            13  C8x C    23.0887  -20.0909
            14  C8x C    21.4475  -14.1800
            15  C8x C    20.1063  -14.5815
            16  C8y C    19.7813  -15.9524
            17  C8x C    20.7996  -16.9132
            18  X   Br   18.4645  -16.3469
            19  O5x O    26.0827  -14.3148
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    1  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19    5  17 2
            20   16  18 1
            21    3  19 2

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