KEGG   DRUG: D01269Help
Entry
D01269                      Drug                                   

Name
Solifenacin succinate (JAN/USAN/INN);
Vesicare (TN)
Product
Formula
C23H26N2O2. C4H6O4
Exact mass
480.226
Mol weight
480.5528
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment for relief of symptoms of urinary frequency, urinary urgency, or urge urinary incontinence (UUI) associated with an overactive bladder [muscarinic M3 receptor antagonist]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor M3 antagonist [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD08 Solifenacin
      D01269  Solifenacin succinate (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Solifenacin
    D01269  Solifenacin succinate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01269  Solifenacin succinate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3
     Solifenacin
      D01269  Solifenacin succinate (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Solifenacin
    D01269  Solifenacin succinate (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
242478-38-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C6a C    27.3377  -15.6723
            2   C1b C    26.1211  -16.3800
            3   O6a O    28.5603  -16.3800
            4   O6a O    27.3377  -14.2742
            5   C1b C    24.9102  -15.6781
            6   C6a C    23.6994  -16.3858
            7   O6a O    22.4826  -15.6840
            8   O6a O    23.6994  -17.7839
            9   C1y C    18.3613  -14.7461
            10  C1x C    18.3613  -13.3364
            11  C1y C    17.1446  -15.4538
            12  C1x C    19.5662  -15.4538
            13  C1x C    19.0456  -14.5531
            14  C1x C    17.8349  -16.6589
            15  C1x C    20.2564  -16.6589
            16  N1y N    19.0398  -15.9627
            17  C1x C    12.3002  -12.6575
            18  C1x C    13.5080  -13.3573
            19  N1y N    13.5080  -14.7568
            20  C1y C    12.3002  -15.4565
            21  C8y C    11.0852  -13.3573
            22  C8y C    11.0852  -14.7568
            23  C8x C     9.8734  -15.4565
            24  C8x C     8.6613  -14.7568
            25  C8x C     8.6613  -13.3573
            26  C8x C     9.8734  -12.6575
            27  C8y C    12.3020  -16.8560
            28  C8x C    13.5154  -17.5532
            29  C8x C    13.5171  -18.9527
            30  C8x C    12.3061  -19.6540
            31  C8x C    11.0932  -18.9558
            32  C8x C    11.0913  -17.5563
            33  C7a C    14.7205  -15.4555
            34  O7a O    15.9321  -14.7549
            35  O6a O    14.7216  -16.8550
BOND        38
            1     6   7 1
            2     6   8 2
            3     1   2 1
            4     1   3 1
            5     1   4 2
            6     2   5 1
            7     5   6 1
            8    21  17 1
            9    17  18 1
            10   18  19 1
            11   19  20 1
            12   20  22 1
            13    9  10 1
            14   21  22 2
            15   22  23 1
            16   23  24 2
            17   24  25 1
            18   25  26 2
            19   26  21 1
            20    9  11 1
            21   20  27 1 #Up
            22    9  12 1
            23   10  13 1
            24   11  14 1
            25   12  15 1
            26   13  16 1
            27   27  28 2
            28   28  29 1
            29   29  30 2
            30   30  31 1
            31   31  32 2
            32   32  27 1
            33   14  16 1
            34   19  33 1
            35   15  16 1
            36   33  34 1
            37   33  35 2
            38   11  34 1 #Down

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