| Entry |
|
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| Name |
Solifenacin succinate (JAN/USAN/INN);
Vesicare (TN)
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| Product |
|
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| Formula |
C23H26N2O2. C4H6O4
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| Exact mass |
480.226
|
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| Mol weight |
480.5528
|
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| Structure |
     |
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| Activity |
Treatment for relief of symptoms of urinary frequency, urinary urgency, or urge urinary incontinence (UUI) associated with an overactive bladder [muscarinic M3 receptor antagonist]
|
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| Remark |
Therapeutic category: ATC code: |
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| Target |
muscarinic cholinergic receptor M3 antagonist [HSA: 1131] [KO: K04131] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D01269 Solifenacin succinate (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Urinary antispasmodics
G04BD08 Solifenacin
D01269 Solifenacin succinate (JAN/USAN/INN)
USP drug classification [BR:br08302]
Genitourinary Agents
Antispasmodics, Urinary
Solifenacin
D01269 Solifenacin succinate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
muscarinic cholinergic receptor M3 [HSA:1131] [KO:K04131]
Solifenacin [ATC:G04BD08]
D01269 Solifenacin succinate (JAN/USAN/INN)
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| Other DBs |
CAS: 242478-38-2 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 35
1 C6a C 35.7376 -17.6322
2 C1b C 34.5210 -18.3399
3 O6a O 36.9602 -18.3399
4 O6a O 35.7376 -16.2341
5 C1b C 33.3101 -17.6380
6 C6a C 32.0993 -18.3457
7 O6a O 30.8825 -17.6439
8 O6a O 32.0993 -19.7438
9 C1y C 26.7612 -16.7060
10 C1x C 26.7612 -15.2963
11 C1y C 25.5445 -17.4137
12 C1x C 27.9661 -17.4137
13 C1x C 27.4455 -16.5130
14 C1x C 26.2348 -18.6188
15 C1x C 28.6563 -18.6188
16 N1y N 27.4397 -17.9226
17 C1x C 20.7001 -14.6174
18 C1x C 21.9079 -15.3172
19 N1y N 21.9079 -16.7167
20 C1y C 20.7001 -17.4164
21 C8y C 19.4851 -15.3172
22 C8y C 19.4851 -16.7167
23 C8x C 18.2733 -17.4164
24 C8x C 17.0612 -16.7167
25 C8x C 17.0612 -15.3172
26 C8x C 18.2733 -14.6174
27 C8y C 20.7019 -18.8159
28 C8x C 21.9153 -19.5131
29 C8x C 21.9170 -20.9126
30 C8x C 20.7060 -21.6139
31 C8x C 19.4931 -20.9157
32 C8x C 19.4912 -19.5162
33 C7a C 23.1204 -17.4154
34 O7a O 24.3320 -16.7148
35 O6a O 23.1215 -18.8149
BOND 38
1 6 7 1
2 6 8 2
3 1 2 1
4 1 3 1
5 1 4 2
6 2 5 1
7 5 6 1
8 21 17 1
9 17 18 1
10 18 19 1
11 19 20 1
12 20 22 1
13 9 10 1
14 21 22 2
15 22 23 1
16 23 24 2
17 24 25 1
18 25 26 2
19 26 21 1
20 9 11 1
21 20 27 1 #Up
22 9 12 1
23 10 13 1
24 11 14 1
25 12 15 1
26 13 16 1
27 27 28 2
28 28 29 1
29 29 30 2
30 30 31 1
31 31 32 2
32 32 27 1
33 14 16 1
34 19 33 1
35 15 16 1
36 33 34 1
37 33 35 2
38 34 11 1
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