KEGG   DRUG: D01285Help
Entry
D01285                      Drug                                   

Name
Lofepramine hydrochloride (JAN/USAN);
Amplit (TN)
Formula
C26H27ClN2O. HCl
Exact mass
454.1579
Mol weight
455.4193
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Therapeutic category: 
ATC code: 
Comment
serotonin noradrenalin reuptake inhibitor
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Interaction
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1174  Imipramines
     D01285  Lofepramine hydrochloride (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA07 Lofepramine
      D01285  Lofepramine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
     Lofepramine [ATC:N06AA07]
      D01285  Lofepramine hydrochloride (JAN/USAN)
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Lofepramine [ATC:N06AA07]
      D01285  Lofepramine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
26786-32-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C1x C    27.9300  -20.5800
            2   C8y C    27.0900  -19.4600
            3   C8y C    27.4400  -18.1300
            4   N1y N    28.7000  -17.5700
            5   C1x C    29.3300  -20.5800
            6   C8y C    29.9600  -18.2000
            7   C8y C    30.2400  -19.5300
            8   C8x C    26.3900  -17.1500
            9   C8x C    25.0600  -17.5700
            10  C8x C    24.7100  -18.9000
            11  C8x C    25.7600  -19.8800
            12  C8x C    31.5700  -19.9500
            13  C8x C    32.6200  -19.0400
            14  C8x C    32.3400  -17.6400
            15  C8x C    31.0100  -17.2200
            16  C1b C    28.7000  -16.1700
            17  C1b C    29.9124  -15.4700
            18  C1b C    31.1079  -16.1604
            19  N1c N    32.2953  -15.4749
            20  C1b C    33.4865  -16.1629
            21  C5a C    34.6760  -15.4762
            22  C8y C    35.8661  -16.1635
            23  O5a O    34.6762  -14.0702
            24  C1a C    32.2955  -14.0702
            25  C8x C    35.8661  -17.5698
            26  C8x C    37.0785  -18.2698
            27  C8y C    38.2909  -17.5699
            28  C8x C    38.2910  -16.1637
            29  C8x C    37.0786  -15.4636
            30  X   Cl   39.5027  -18.2696
            31  X   Cl   36.4000  -20.1600
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   21  23 2
            26   19  24 1
            27   22  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   22  29 1
            33   27  30 1

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