| Entry |
|
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| Name |
Levobupivacaine hydrochloride (JAN/USAN);
Chirocaine (TN) |
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| Formula |
C18H28N2O. HCl
|
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| Exact mass |
324.1968
|
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| Mol weight |
324.8887
|
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1214 |
| Product (DG00807): | D01287<JP> |
|
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| Efficacy |
Anesthetic (local), Analgesic |
|---|
| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01B ANESTHETICS, LOCAL
N01BB Amides
N01BB10 Levobupivacaine
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
121 Local anesthetics
1214 Xylidines
D01287 Levobupivacaine hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00807 Levobupivacaine
D01287 Levobupivacaine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00807 Levobupivacaine
D01287 Levobupivacaine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00807 Levobupivacaine
D01287 Levobupivacaine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN2A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN3A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN4A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN5A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN8A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN9A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN10A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
SCN11A
D01287 Levobupivacaine hydrochloride (JAN/USAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01287
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01287
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00807 Levobupivacaine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00807 Levobupivacaine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00807 Levobupivacaine
|
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| Other DBs |
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| KCF data |
ATOM 22
1 C1y C 26.0358 -18.8835
2 N1y N 26.0184 -20.2817
3 C5a C 24.8241 -18.1727
4 C1x C 27.2477 -18.1843
5 C1x C 27.2301 -20.9866
6 C1b C 24.8008 -20.9692
7 N1b N 23.6122 -18.8661
8 O5a O 24.8357 -16.7687
9 C1x C 28.4535 -18.8951
10 C1x C 28.4478 -20.2991
11 C1b C 23.6005 -20.2701
12 C8y C 22.4004 -18.1553
13 C1b C 22.3888 -20.9633
14 C8y C 21.1828 -18.8485
15 C8y C 22.4121 -16.7511
16 C1a C 22.3888 -22.3558
17 C8x C 19.9768 -18.1377
18 C1a C 21.1828 -20.2409
19 C8x C 21.2002 -16.0462
20 C1a C 23.3966 -15.7433
21 C8x C 19.9768 -16.7395
22 X Cl 31.4327 -19.6720
BOND 22
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 11 13 1
13 12 14 1
14 12 15 2
15 13 16 1
16 14 17 2
17 14 18 1
18 15 19 1
19 15 20 1
20 17 21 1
21 9 10 1
22 19 21 2
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