KEGG   DRUG: Levobupivacaine hydrochlorideHelp
Entry
D01287                      Drug                                   

Name
Levobupivacaine hydrochloride (JAN/USAN);
Chirocaine (TN)
Formula
C18H28N2O. HCl
Exact mass
324.1968
Mol weight
324.8887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anesthetic (local), Analgesic
Target
SCN10A [HSA:6336] [KO:K04842];
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB10 Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D01287  Levobupivacaine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN2A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN3A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN4A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN5A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN8A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN9A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
    voltage-gated sodium channel (SCN10A)
     Levobupivacaine
      D01287  Levobupivacaine hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Levobupivacaine
    D01287  Levobupivacaine hydrochloride (JAN/USAN)
  CYP3A4
   Levobupivacaine
    D01287  Levobupivacaine hydrochloride (JAN/USAN)
Anesthetics and analgesics [br08369.html]
 Anesthetics
  D01287
BRITE hierarchy
Other DBs
CAS: 
27262-48-2
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        22
            1   C1y C    26.0358  -18.8835
            2   N1y N    26.0184  -20.2817
            3   C5a C    24.8241  -18.1727
            4   C1x C    27.2477  -18.1843
            5   C1x C    27.2301  -20.9866
            6   C1b C    24.8008  -20.9692
            7   N1b N    23.6122  -18.8661
            8   O5a O    24.8357  -16.7687
            9   C1x C    28.4535  -18.8951
            10  C1x C    28.4478  -20.2991
            11  C1b C    23.6005  -20.2701
            12  C8y C    22.4004  -18.1553
            13  C1b C    22.3888  -20.9633
            14  C8y C    21.1828  -18.8485
            15  C8y C    22.4121  -16.7511
            16  C1a C    22.3888  -22.3558
            17  C8x C    19.9768  -18.1377
            18  C1a C    21.1828  -20.2409
            19  C8x C    21.2002  -16.0462
            20  C1a C    23.3966  -15.7433
            21  C8x C    19.9768  -16.7395
            22  X   Cl   31.4327  -19.6720
BOND        22
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12   11  13 1
            13   12  14 1
            14   12  15 2
            15   13  16 1
            16   14  17 2
            17   14  18 1
            18   15  19 1
            19   15  20 1
            20   17  21 1
            21    9  10 1
            22   19  21 2

» Japanese version   » Back

DBGET integrated database retrieval system