KEGG   DRUG: D01295Help
Entry
D01295                      Drug                                   

Name
Cinnarizine (JAN/USAN/INN)
Formula
C26H28N2
Exact mass
368.2252
Mol weight
368.5139
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07C ANTIVERTIGO PREPARATIONS
    N07CA Antivertigo preparations
     N07CA02 Cinnarizine
      D01295  Cinnarizine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Cinnarizine
      D01295  Cinnarizine (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Cinnarizine
    D01295  Cinnarizine (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
298-57-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8x C     7.7700  -17.9900
            2   C8x C     7.7700  -19.3900
            3   C8x C     8.9824  -20.0900
            4   C8x C    10.1949  -19.3900
            5   C8y C    10.1949  -17.9900
            6   C8x C     8.9824  -17.2900
            7   C8x C    12.6197  -19.3900
            8   C8y C    12.6197  -17.9900
            9   C1c C    11.4073  -17.2900
            10  C8x C    13.8322  -20.0900
            11  C8x C    15.0446  -19.3900
            12  C8x C    15.0446  -17.9900
            13  C8x C    13.8322  -17.2900
            14  N1y N    11.4073  -15.8900
            15  C1x C    12.6218  -15.1888
            16  C1x C    12.6218  -13.7888
            17  N1y N    11.4093  -13.0888
            18  C1x C    10.1949  -13.7900
            19  C1x C    10.1949  -15.1900
            20  C1b C    11.4093  -11.6900
            21  C2b C    12.6223  -10.9897
            22  C2b C    13.8180  -11.6802
            23  C8y C    15.0052  -10.9949
            24  C8x C    16.1965  -11.6829
            25  C8x C    17.4091  -10.9830
            26  C8x C    17.4092   -9.5830
            27  C8x C    16.2179   -8.8950
            28  C8x C    15.0054   -9.5949
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22   17  20 1
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1

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