KEGG   DRUG: D01303Help
Entry
D01303                      Drug                                   

Name
Flunarizine hydrochloride (JAN/USAN)
Formula
C26H26F2N2. 2HCl
Exact mass
476.1598
Mol weight
477.4167
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator
Remark
ATC code: 
Drug group: 
Target
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07C ANTIVERTIGO PREPARATIONS
    N07CA Antivertigo preparations
     N07CA03 Flunarizine
      D01303  Flunarizine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type
     Flunarizine
      D01303  Flunarizine hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Flunarizine
    D01303  Flunarizine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
30484-77-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1c C    32.9047  -20.4996
            2   C8y C    31.6903  -21.1975
            3   C8y C    34.1164  -21.2023
            4   C8x C    30.4848  -20.4979
            5   C8x C    29.2704  -21.1960
            6   C8y C    29.2677  -22.5966
            7   C8x C    30.4794  -23.2991
            8   C8x C    31.6936  -22.6012
            9   C8x C    34.1060  -22.6017
            10  C8x C    35.3177  -23.3044
            11  C8y C    36.5320  -22.6066
            12  C8x C    36.5349  -21.2060
            13  C8x C    35.3231  -20.5033
            14  X   F    28.0533  -23.2944
            15  X   F    37.7437  -23.3093
            16  N1y N    32.9074  -19.0988
            17  C1x C    34.1218  -18.4009
            18  C1x C    34.1245  -17.0003
            19  N1y N    32.9130  -16.2976
            20  C1x C    31.6987  -16.9954
            21  C1x C    31.6959  -18.3960
            22  C1b C    32.9158  -14.8970
            23  C2b C    34.1301  -14.1989
            24  C2b C    35.3684  -14.9170
            25  C8y C    36.5712  -14.2255
            26  C8x C    37.7523  -14.9103
            27  C8x C    38.9660  -14.2126
            28  C8x C    38.9686  -12.8126
            29  C8x C    37.7876  -12.1278
            30  C8x C    36.5739  -12.8255
            31  X   Cl   38.3236  -17.8908
            32  X   Cl   38.3236  -17.8908
BOND        33
            1    16  17 1
            2    17  18 1
            3    18  19 1
            4    19  20 1
            5    20  21 1
            6    21  16 1
            7     1   2 1
            8    19  22 1
            9     1   3 1
            10    3   9 2
            11    9  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13   3 1
            16    2   4 2
            17    6  14 1
            18   22  23 1
            19    4   5 1
            20   11  15 1
            21    5   6 2
            22    1  16 1
            23    6   7 1
            24    7   8 2
            25    8   2 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   25  30 1
BRACKET     1    36.7500  -18.6200   36.7500  -17.2200
            1    39.1300  -17.2200   39.1300  -18.6200
            1  2
 ORIGINAL  1   31
 REPEAT    1   32

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