KEGG   DRUG: D01307Help
Entry
D01307                      Drug                                   

Name
Midodrine hydrochloride (JAN/USAN);
Pro-Amatine (TN)
Product
  Generic
MIDODRINE HCL (American Health Packaging), MIDODRINE HYDROCHLORIDE (American Health Packaging), MIDODRINE HYDROCHLORIDE (Apotex Corp), MIDODRINE HYDROCHLORIDE (AvKARE), MIDODRINE HYDROCHLORIDE (AvPAK), MIDODRINE HCL (Cardinal Health), MIDODRINE HYDROCHLORIDE (Cardinal Health), MIDODRINE HCL (Cardinal Health), MIDODRINE HCL (Cardinal Health), MIDODRINE HYDROCHLORIDE (Carilion Materials Management), MIDODRINE HCL (Eon Labs), MIDODRINE HYDROCHLORIDE (Global Pharmaceuticals), MIDODRINE HCL (McKesson Packaging Services a business unit of McKesson Corporation), MIDODRINE HYDROCHLORIDE (Mylan Institutional), MIDODRINE HYDROCHLORIDE (Mylan Pharmaceuticals), MIDODRINE HYDROCHLORIDE (NCS HealthCare of KY), MIDODRINE HYDROCHLORIDE (Physicians Total Care), MIDODRINE HCL (Rebel Distributors Corp), MIDODRINE HYDROCHLORIDE (Upsher-Smith Laboratories)
Formula
C12H18N2O4. HCl
Exact mass
290.1033
Mol weight
290.7433
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypotensive
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Salivary secretion
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA17 Midodrine
      D01307  Midodrine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Midodrine
    D01307  Midodrine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D01307  Midodrine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Midodrine
      D01307  Midodrine hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2D6
   Midodrine
    D01307  Midodrine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
3092-17-9
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        19
            1   X   Cl   27.9649  -19.4803
            2   C8y C    17.4300  -16.0300
            3   C8x C    17.4300  -17.4300
            4   C8x C    18.6200  -18.1300
            5   C8y C    19.8800  -17.4300
            6   C8y C    19.8800  -16.0300
            7   C8x C    18.6200  -15.3300
            8   C1c C    21.0700  -15.3300
            9   C1b C    22.2600  -16.0300
            10  O1a O    21.0700  -13.9300
            11  N1b N    23.4500  -15.3300
            12  C5a C    24.7100  -16.0300
            13  C1b C    25.9000  -15.3300
            14  N1a N    27.0900  -16.0300
            15  O5a O    24.7100  -17.4300
            16  O2a O    16.1700  -15.3300
            17  C1a C    14.9800  -16.0300
            18  O2a O    21.0700  -18.1300
            19  C1a C    21.0700  -19.5300
BOND        18
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     8  10 1
            10    9  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   12  15 2
            15    2  16 1
            16   16  17 1
            17    5  18 1
            18   18  19 1

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