KEGG   DRUG: D01316Help
Entry
D01316                      Drug                                   
Name
Mexazolam (JAN/INN);
Melex (TN)
Formula
C18H16Cl2N2O2
Exact mass
362.0589
Mol weight
363.2378
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anxiolytic
Remark
Therapeutic category: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Anxiolytics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01316  Mexazolam (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Mexazolam
      D01316  Mexazolam (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
31868-18-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C1z C    22.2873  -12.4810
            2   C8y C    21.4533  -11.3820
            3   C8y C    21.7853  -10.0384
            4   N1x N    23.0341   -9.4657
            5   N1y N    23.6795  -12.4366
            6   C5x C    24.2756  -10.0821
            7   C1x C    24.5594  -11.4377
            8   C8x C    20.7878   -9.0793
            9   C8x C    19.4588   -9.4636
            10  C8y C    19.1268  -10.8073
            11  C8x C    20.1242  -11.7661
            12  O5x O    25.3097   -9.1567
            13  X   Cl   17.7752  -11.1980
            14  O2x O    21.8992  -13.8188
            15  C1x C    23.0516  -14.6013
            16  C1y C    24.1519  -13.7471
            17  C8y C    20.6024  -13.1737
            18  C8x C    19.4025  -12.4810
            19  C8x C    18.2026  -13.1737
            20  C8x C    18.2026  -14.5593
            21  C8x C    19.4025  -15.2521
            22  C8y C    20.6024  -14.5593
            23  X   Cl   21.8088  -15.2559
            24  C1a C    25.4873  -14.1342
BOND        27
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 1
            18    5  16 1
            19    1  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   21  22 2
            25   17  22 1
            26   22  23 1
            27   16  24 1

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