KEGG   DRUG: D01321Help
Entry
D01321                      Drug                                   

Name
Zotepine (JAN/INN);
Setous (TN)
Formula
C18H18ClNOS
Exact mass
331.0798
Mol weight
331.8596
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic
Remark
Therapeutic category: 
ATC code: 
Comment
Tiepine derivatives
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antipsychotics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX11 Zotepine
      D01321  Zotepine (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01321  Zotepine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Zotepine
      D01321  Zotepine (JAN/INN)
   Serotonin
    5-HT2A-receptor
     Zotepine
      D01321  Zotepine (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Zotepine
    D01321  Zotepine (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
26615-21-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C2y C    52.5000   -9.9400
            2   C8y C    51.6600   -8.8200
            3   C8y C    52.0100   -7.4900
            4   S2x S    53.2700   -6.9300
            5   C2x C    53.9000   -9.9400
            6   C8y C    54.5300   -7.5600
            7   C8y C    54.8100   -8.8900
            8   C8x C    50.9600   -6.5100
            9   C8x C    49.6300   -6.9300
            10  C8y C    49.2800   -8.2600
            11  C8x C    50.3300   -9.2400
            12  C8x C    56.1400   -9.3100
            13  C8x C    57.1900   -8.4000
            14  C8x C    56.9100   -7.0000
            15  C8x C    55.5800   -6.5800
            16  X   Cl   47.9500   -8.6800
            17  O2a O    51.8700  -11.2000
            18  C1b C    50.4700  -11.2000
            19  C1b C    49.7700  -12.3900
            20  N1c N    48.3700  -12.3900
            21  C1a C    47.6700  -11.1776
            22  C1a C    47.6700  -13.6024
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18   10  16 1
            19    1  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 1

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