KEGG   DRUG: D01322Help
Entry
D01322                      Drug                                   

Name
Triacetyloleandomycin (JAN);
Troleandomycin (USP/INN);
TAO;
Tao (TN)
Formula
C41H67NO15
Exact mass
813.4511
Mol weight
813.9684
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
ATC code: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA08 Troleandomycin
      D01322  Triacetyloleandomycin (JAN); Troleandomycin (USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Troleandomycin
      D01322  Triacetyloleandomycin (JAN); Troleandomycin (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Troleandomycin
    D01322  Triacetyloleandomycin (JAN); Troleandomycin (USP/INN)
 Inhbitors
  CYP3A4
   Troleandomycin
    D01322  Triacetyloleandomycin (JAN); Troleandomycin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
2751-09-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        57
            1   C1z C    21.0419  -12.6310
            2   C1x C    21.1002  -11.2073
            3   O2x O    22.3239  -11.9250
            4   C1x C    21.0419  -14.0309
            5   C5x C    19.8302  -11.9250
            6   C1y C    22.2597  -14.7193
            7   C1y C    18.6242  -12.6310
            8   O5x O    19.8302  -10.5367
            9   C1y C    22.2597  -16.1194
            10  C1a C    23.4598  -14.0251
            11  C1y C    18.6242  -14.0309
            12  C1a C    17.4123  -11.9250
            13  C1y C    21.0419  -16.8193
            14  O2a O    23.7339  -17.0293
            15  C1y C    17.4123  -14.7193
            16  C1y C    21.0419  -18.2136
            17  C1a C    19.8302  -16.1194
            18  C1y C    25.8399  -16.7900
            19  C1y C    17.4123  -16.1194
            20  C1a C    16.2065  -14.0251
            21  O2a O    22.2597  -18.9078
            22  C1y C    19.8302  -18.9078
            23  C1y C    26.5164  -15.5723
            24  O2x O    26.5576  -17.9842
            25  O7x O    18.6242  -16.8193
            26  C1a C    16.2005  -16.8253
            27  C1y C    22.3456  -20.5820
            28  C7x C    18.6242  -18.2136
            29  C1a C    19.8302  -20.3019
            30  C1y C    27.9107  -15.5487
            31  O7a O    25.7869  -14.3663
            32  C1y C    27.9458  -17.9606
            33  C1x C    22.3456  -21.9879
            34  O2x O    23.5516  -19.8878
            35  O6a O    17.4123  -18.9078
            36  C1x C    28.6224  -16.7429
            37  N1c N    28.5871  -14.3310
            38  C1y C    23.5516  -22.6762
            39  C1y C    24.7576  -20.5820
            40  C1a C    29.9754  -14.3774
            41  C1y C    24.7576  -21.9879
            42  O2a O    23.5576  -24.0704
            43  C1a C    25.9635  -19.8878
            44  O7a O    25.9635  -22.6762
            45  C1a C    22.3516  -24.7703
            46  C7a C    25.7792  -12.9563
            47  C1a C    26.9940  -12.2459
            48  O6a O    24.5564  -12.2594
            49  O7a O    16.6995  -12.9760
            50  C7a C    15.4768  -12.2723
            51  O6a O    15.4749  -10.8648
            52  C1a C    14.2589  -12.9775
            53  C7a C    27.1790  -21.9665
            54  C1a C    28.4014  -22.6641
            55  O6a O    27.1720  -20.5591
            56  C1a C    28.5871  -12.9310
            57  C1a C    28.6749  -19.1754
BOND        60
            1     7  11 1
            2     7  12 1 #Up
            3     9  13 1
            4     9  14 1 #Down
            5    11  15 1
            6    13  16 1
            7    13  17 1 #Down
            8    18  14 1 #Up
            9    15  19 1
            10   15  20 1 #Down
            11   16  21 1 #Down
            12   16  22 1
            13   18  23 1
            14   18  24 1
            15   19  25 1
            16   19  26 1 #Down
            17   27  21 1 #Down
            18   22  28 1
            19   22  29 1 #Up
            20   23  30 1
            21   23  31 1 #Down
            22   24  32 1
            23   27  33 1
            24   27  34 1
            25   28  35 2
            26   30  36 1
            27   30  37 1 #Up
            28   33  38 1
            29   34  39 1
            30   37  40 1
            31   38  41 1
            32   38  42 1 #Up
            33   39  43 1 #Up
            34   41  44 1 #Down
            35   42  45 1
            36    2   3 1
            37   25  28 1
            38   32  36 1
            39   39  41 1
            40   31  46 1
            41    1   2 1
            42   46  47 1
            43    1   3 1 #Up
            44   46  48 2
            45    1   4 1
            46   11  49 1 #Up
            47    1   5 1
            48   49  50 1
            49    4   6 1
            50   50  51 2
            51    5   7 1
            52   50  52 1
            53    5   8 2
            54   44  53 1
            55    6   9 1
            56   53  54 1
            57    6  10 1 #Down
            58   53  55 2
            59   37  56 1
            60   32  57 1 #Up

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