KEGG   DRUG: D01323Help
Entry
D01323                      Drug                                   

Name
Azosemide (JAN/USAN/INN);
Diart (TN)
Formula
C12H11ClN6O2S2
Exact mass
370.0073
Mol weight
370.8377
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Therapeutic category: 
Comment
loop diuretic
Target
Na-K-Cl cotransporter 1 inhibitor [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 inhibitor [HSA:6558] [KO:K10951]
  Pathway
hsa04970  Salivary secretion
hsa04972  Pancreatic secretion  
 
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D01323  Azosemide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Azosemide
      D01323  Azosemide (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
27589-33-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8x C    17.6727  -20.0852
            2   C8y C    18.1088  -18.7538
            3   S2x S    16.9723  -17.9271
            4   C8x C    15.8359  -18.7538
            5   C8x C    16.2718  -20.0852
            6   N5x N    20.1037  -14.6239
            7   N5x N    18.7096  -14.6247
            8   N5x N    18.2796  -15.9509
            9   N4x N    19.4080  -16.7694
            10  C8y C    20.5352  -15.9494
            11  C8y C    21.7481  -16.6505
            12  C8y C    21.7481  -18.0514
            13  C8x C    22.9643  -18.7519
            14  C8y C    24.1733  -18.0514
            15  C8y C    24.1733  -16.6505
            16  C8x C    22.9643  -15.9501
            17  N1b N    20.5352  -18.7524
            18  C1b C    19.3218  -18.0526
            19  S4a S    25.3871  -15.9509
            20  X   Cl   25.3871  -18.7509
            21  O3c O    26.5997  -16.6522
            22  N1a N    26.5948  -15.2425
            23  O3c O    24.1679  -15.2496
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5    11  12 2
            6    12  13 1
            7    13  14 2
            8    14  15 1
            9    15  16 2
            10   16  11 1
            11   11  10 1
            12    6   7 1
            13   12  17 1
            14    7   8 2
            15   17  18 1
            16   18   2 1
            17    8   9 1
            18   15  19 1
            19    9  10 1
            20   14  20 1
            21   10   6 2
            22   19  21 2
            23    5   1 1
            24   19  22 1
            25   19  23 2

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