KEGG   DRUG: AzosemideHelp
Entry
D01323                      Drug                                   

Name
Azosemide (JAN/USAN/INN);
Diart (TN)
Formula
C12H11ClN6O2S2
Exact mass
370.0073
Mol weight
370.8377
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Remark
Therapeutic category: 
Activity
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425];
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
  Pathway
Salivary secretion
Pancreatic secretion
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D01323  Azosemide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Azosemide
      D01323  Azosemide (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
27589-33-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8x C    17.6727  -20.0852
            2   C8y C    18.1088  -18.7538
            3   S2x S    16.9723  -17.9271
            4   C8x C    15.8359  -18.7538
            5   C8x C    16.2718  -20.0852
            6   N5x N    20.1037  -14.6239
            7   N5x N    18.7096  -14.6247
            8   N5x N    18.2796  -15.9509
            9   N4x N    19.4080  -16.7694
            10  C8y C    20.5352  -15.9494
            11  C8y C    21.7481  -16.6505
            12  C8y C    21.7481  -18.0514
            13  C8x C    22.9643  -18.7519
            14  C8y C    24.1733  -18.0514
            15  C8y C    24.1733  -16.6505
            16  C8x C    22.9643  -15.9501
            17  N1b N    20.5352  -18.7524
            18  C1b C    19.3218  -18.0526
            19  S4a S    25.3871  -15.9509
            20  X   Cl   25.3871  -18.7509
            21  O3c O    26.5997  -16.6522
            22  N1a N    26.5948  -15.2425
            23  O3c O    24.1679  -15.2496
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5    11  12 2
            6    12  13 1
            7    13  14 2
            8    14  15 1
            9    15  16 2
            10   16  11 1
            11   11  10 1
            12    6   7 1
            13   12  17 1
            14    7   8 2
            15   17  18 1
            16   18   2 1
            17    8   9 1
            18   15  19 1
            19    9  10 1
            20   14  20 1
            21   10   6 2
            22   19  21 2
            23    5   1 1
            24   19  22 1
            25   19  23 2

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