KEGG   DRUG: D01326Help
Entry
D01326                      Drug                                   

Name
Aprindine hydrochloride (JP16/USAN);
Aspenon (TN)
Formula
C22H30N2. HCl
Exact mass
358.2176
Mol weight
358.9479
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ib)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB04 Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01326  Aprindine hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
    voltage-gated sodium channel (SCN2A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
    voltage-gated sodium channel (SCN3A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
    voltage-gated sodium channel (SCN4A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
    voltage-gated sodium channel (SCN5A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
    voltage-gated sodium channel (SCN8A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
    voltage-gated sodium channel (SCN9A)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2)
     Aprindine
      D01326  Aprindine hydrochloride (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Aprindine
    D01326  Aprindine hydrochloride (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01326  Aprindine hydrochloride
  D01326  Aprindine hydrochloride capsules
BRITE hierarchy
Other DBs
CAS: 
33237-74-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   X   Cl   32.7915  -19.2578
            2   N1c N    26.5338  -17.9795
            3   C1b C    26.5338  -16.5753
            4   C1b C    27.7273  -15.8732
            5   C1b C    28.9208  -16.5753
            6   N1c N    30.1845  -15.8732
            7   C1b C    31.3780  -16.5753
            8   C1a C    32.5715  -15.8732
            9   C1b C    30.1845  -14.4692
            10  C1a C    31.3780  -13.7671
            11  C8y C    27.7273  -18.6815
            12  C8x C    27.7273  -20.0856
            13  C8x C    28.9910  -20.7877
            14  C8x C    30.1845  -20.0856
            15  C8x C    30.1845  -18.6815
            16  C8x C    28.9208  -17.9795
            17  C1y C    25.3541  -18.6537
            18  C1x C    25.3481  -20.0476
            19  C1x C    24.0304  -18.2171
            20  C8y C    23.2061  -19.3413
            21  C8y C    24.0205  -20.4726
            22  C8x C    21.9150  -19.3243
            23  C8x C    21.2284  -20.6165
            24  C8x C    21.9395  -21.7455
            25  C8x C    23.3412  -21.7991
BOND        26
            1     3   4 1
            2     7   8 1
            3    11  12 2
            4    12  13 1
            5    13  14 2
            6    14  15 1
            7    15  16 2
            8    16  11 1
            9     6   9 1
            10    4   5 1
            11    9  10 1
            12    2   3 1
            13    2  11 1
            14    5   6 1
            15    6   7 1
            16    2  17 1
            17   17  18 1
            18   17  19 1
            19   19  20 1
            20   20  21 1
            21   18  21 1
            22   20  22 2
            23   22  23 1
            24   23  24 2
            25   24  25 1
            26   21  25 2

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