KEGG   DRUG: D01328Help
Entry
D01328                      Drug                                   
Name
Clotiazepam (JP16/INN);
Rize (TN)
Formula
C16H15ClN2OS
Exact mass
318.0594
Mol weight
318.8211
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
Anxiolytics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01328  Clotiazepam (JP16/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA21 Clotiazepam
      D01328  Clotiazepam (JP16/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Clotiazepam [ATC:N05BA21]
      D01328  Clotiazepam (JP16/INN)
BRITE hierarchy
Other DBs
CAS: 
33671-46-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C2y C    20.4334  -14.2894
            2   C8y C    19.5913  -13.1798
            3   C8y C    19.9265  -11.8230
            4   N1y N    21.1875  -11.2449
            5   N2x N    21.8392  -14.3146
            6   C5x C    22.4411  -11.8672
            7   C1x C    22.7276  -13.2359
            8   O5x O    23.4852  -10.9328
            9   C8y C    19.7989  -15.5391
            10  C8x C    18.3973  -15.5391
            11  S2x S    18.7397  -11.0849
            12  C8y C    17.6710  -11.9856
            13  C8x C    18.1973  -13.2802
            14  C8x C    17.6973  -16.7516
            15  C8x C    18.3973  -17.9640
            16  C8x C    19.7989  -17.9640
            17  C8y C    20.4989  -16.7516
            18  X   Cl   21.9098  -16.7517
            19  C1b C    16.2710  -11.9856
            20  C1a C    15.5569  -10.7480
            21  C1a C    21.2092   -9.8700
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     1   9 1
            10    9  10 1
            11    3  11 1
            12   11  12 1
            13   12  13 2
            14    2  13 1
            15   10  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19    9  17 2
            20   17  18 1
            21   12  19 1
            22   19  20 1
            23    4  21 1

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