KEGG   DRUG: Epoprostenol sodiumHelp
Entry
D01337                      Drug                                   

Name
Epoprostenol sodium (JAN/USAN);
Flolan (TN)
Product
Formula
C20H31O5. Na
Exact mass
374.2069
Mol weight
374.4469
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01810  Prostacycline derivative
Unclassified
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Inhibitor [platelet]
  Disease
Pulmonary arterial hypertension [DS:H01621]
Target
prostaglandin I2 receptor [HSA:5739] [KO:K04263]
  Pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
Eicosanoids
Antithrombosis agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC09 Epoprostenol
      D01337  Epoprostenol sodium (JAN/USAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Epoprostenol
    D01337  Epoprostenol sodium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D01337  Epoprostenol sodium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    prostaglandin I2 receptor
     Epoprostenol
      D01337  Epoprostenol sodium (JAN/USAN)
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01337
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01337
BRITE hierarchy
Other DBs
CAS: 
61849-14-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   Z   Na   26.1044  -10.2395 #+
            2   C1y C    25.1300  -19.0400
            3   C1y C    23.8000  -18.6200
            4   C1y C    25.1300  -20.4400
            5   C1x C    25.8300  -17.7800
            6   O2x O    23.8000  -17.1500
            7   C1x C    23.0300  -19.7400
            8   C1y C    23.8700  -20.8600
            9   C2b C    26.3200  -21.1400
            10  C2y C    25.1300  -16.5200
            11  O1a O    23.3800  -22.1900
            12  C2b C    27.5100  -20.4400
            13  C2b C    26.3200  -15.8200
            14  C1c C    28.7000  -21.1400
            15  C1b C    29.9600  -20.4400
            16  O1a O    28.7000  -22.4700
            17  C1b C    31.1500  -21.1400
            18  C1b C    32.3400  -20.4400
            19  C1b C    33.5300  -21.1400
            20  C1a C    34.7200  -20.4400
            21  C1b C    26.3900  -14.4200
            22  C1b C    27.5800  -13.7200
            23  C1b C    27.5800  -12.3200
            24  C6a C    28.7700  -11.6200
            25  O6a O    30.0300  -12.3200
            26  O6a O    28.7700  -10.2200 #-
BOND        26
            1     2   3 1
            2     2   4 1
            3     2   5 1 #Down
            4     3   6 1 #Down
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Up
            8     5  10 1
            9     8  11 1 #Down
            10    9  12 2
            11   10  13 2
            12   12  14 1
            13   14  15 1
            14   14  16 1 #Down
            15   15  17 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19    6  10 1
            20    7   8 1
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 2
            26   24  26 1

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