| Entry |
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| Name |
Epoprostenol sodium (JAN/USAN);
Flolan (TN)
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| Product |
|
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| Formula |
C20H31O5. Na
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| Exact mass |
374.2069
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| Mol weight |
374.4469
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| Structure |
     |
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| Activity |
Inhibitor [platelet]
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| Remark |
Therapeutic category: ATC code: |
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| Target |
prostaglandin I2 receptor agonist [HSA: 5739] [KO: K04263] |
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| Pathway |
hsa04080 Neuroactive ligand-receptor interaction
hsa04270 Vascular smooth muscle contraction | |
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| Interaction |
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| Structure map |
| Eicosanoids | | Antithrombosis agents | | Eicosanoid receptor agonists/antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D01337 Epoprostenol sodium (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC09 Epoprostenol
D01337 Epoprostenol sodium (JAN/USAN)
USP drug classification [BR:br08302]
Respiratory Tract Agents
Pulmonary Antihypertensives
Prostacycline Vasodilators
Epoprostenol
D01337 Epoprostenol sodium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostacyclin
prostaglandin I2 receptor [HSA:5739] [KO:K04263]
Epoprostenol [ATC:B01AC09]
D01337 Epoprostenol sodium (JAN/USAN)
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| Other DBs |
CAS: 61849-14-7 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 26
1 Z Na 26.1044 -10.2395 #+
2 C1y C 25.1300 -19.0400
3 C1y C 23.8000 -18.6200
4 C1y C 25.1300 -20.4400
5 C1x C 25.8300 -17.7800
6 O2x O 23.8000 -17.1500
7 C1x C 23.0300 -19.7400
8 C1y C 23.8700 -20.8600
9 C2b C 26.3200 -21.1400
10 C2y C 25.1300 -16.5200
11 O1a O 23.3800 -22.1900
12 C2b C 27.5100 -20.4400
13 C2b C 26.3200 -15.8200
14 C1c C 28.7000 -21.1400
15 C1b C 29.9600 -20.4400
16 O1a O 28.7000 -22.4700
17 C1b C 31.1500 -21.1400
18 C1b C 32.3400 -20.4400
19 C1b C 33.5300 -21.1400
20 C1a C 34.7200 -20.4400
21 C1b C 26.3900 -14.4200
22 C1b C 27.5800 -13.7200
23 C1b C 27.5800 -12.3200
24 C6a C 28.7700 -11.6200
25 O6a O 30.0300 -12.3200
26 O6a O 28.7700 -10.2200 #-
BOND 26
1 2 3 1
2 2 4 1
3 2 5 1 #Down
4 3 6 1 #Down
5 3 7 1
6 4 8 1
7 4 9 1 #Up
8 5 10 1
9 8 11 1 #Down
10 9 12 2
11 10 13 2
12 12 14 1
13 14 15 1
14 14 16 1 #Down
15 15 17 1
16 17 18 1
17 18 19 1
18 19 20 1
19 6 10 1
20 7 8 1
21 13 21 1
22 21 22 1
23 22 23 1
24 23 24 1
25 24 25 2
26 24 26 1
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