KEGG   DRUG: D01337Help
Entry
D01337                      Drug                                   

Name
Epoprostenol sodium (JAN/USAN);
Flolan (TN)
Product
Formula
C20H31O5. Na
Exact mass
374.2069
Mol weight
374.4469
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibitor [platelet]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
prostaglandin I2 receptor agonist [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Eicosanoids
Antithrombosis agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC09 Epoprostenol
      D01337  Epoprostenol sodium (JAN/USAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Epoprostenol
    D01337  Epoprostenol sodium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D01337  Epoprostenol sodium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    prostaglandin I2 receptor
     Epoprostenol
      D01337  Epoprostenol sodium (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
61849-14-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   Z   Na   26.1044  -10.2395 #+
            2   C1y C    25.1300  -19.0400
            3   C1y C    23.8000  -18.6200
            4   C1y C    25.1300  -20.4400
            5   C1x C    25.8300  -17.7800
            6   O2x O    23.8000  -17.1500
            7   C1x C    23.0300  -19.7400
            8   C1y C    23.8700  -20.8600
            9   C2b C    26.3200  -21.1400
            10  C2y C    25.1300  -16.5200
            11  O1a O    23.3800  -22.1900
            12  C2b C    27.5100  -20.4400
            13  C2b C    26.3200  -15.8200
            14  C1c C    28.7000  -21.1400
            15  C1b C    29.9600  -20.4400
            16  O1a O    28.7000  -22.4700
            17  C1b C    31.1500  -21.1400
            18  C1b C    32.3400  -20.4400
            19  C1b C    33.5300  -21.1400
            20  C1a C    34.7200  -20.4400
            21  C1b C    26.3900  -14.4200
            22  C1b C    27.5800  -13.7200
            23  C1b C    27.5800  -12.3200
            24  C6a C    28.7700  -11.6200
            25  O6a O    30.0300  -12.3200
            26  O6a O    28.7700  -10.2200 #-
BOND        26
            1     2   3 1
            2     2   4 1
            3     2   5 1 #Down
            4     3   6 1 #Down
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Up
            8     5  10 1
            9     8  11 1 #Down
            10    9  12 2
            11   10  13 2
            12   12  14 1
            13   14  15 1
            14   14  16 1 #Down
            15   15  17 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19    6  10 1
            20    7   8 1
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 2
            26   24  26 1

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