KEGG   DRUG: D01343Help
Entry
D01343                      Drug                                   

Name
Dimetindene maleate (JAN);
Dimethindene maleate (USAN);
Forhistal maleate (TN)
Formula
C20H24N2. C4H4O4
Exact mass
408.2049
Mol weight
408.4901
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA13 Dimetindene
      D01343  Dimetindene maleate (JAN); Dimethindene maleate (USAN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB03 Dimetindene
      D01343  Dimetindene maleate (JAN); Dimethindene maleate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dimetindene
      D01343  Dimetindene maleate (JAN); Dimethindene maleate (USAN)
BRITE hierarchy
Other DBs
CAS: 
3614-69-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C8x C    20.8688  -16.1854
            2   C8x C    20.8688  -17.5844
            3   C8x C    22.0834  -18.2840
            4   C8x C    22.0834  -15.4859
            5   C8y C    23.2908  -16.1854
            6   C8y C    23.2848  -17.5878
            7   C1x C    24.6169  -18.0269
            8   C2y C    25.4458  -16.8956
            9   C2y C    24.6264  -15.7575
            10  C1b C    26.8449  -16.9014
            11  C1b C    27.5393  -18.1159
            12  N1c N    28.9383  -18.1217
            13  C1a C    29.6330  -19.3362
            14  C1a C    29.6430  -16.9131
            15  C1c C    24.6137  -14.3553
            16  C8y C    25.8191  -13.6449
            17  C1a C    23.3959  -13.6668
            18  C8x C    27.0316  -14.3356
            19  C8x C    28.2368  -13.6252
            20  C8x C    28.2242  -12.2262
            21  C8x C    27.0063  -11.5377
            22  N5x N    25.8011  -12.2481
            23  C6a C    38.0303  -15.9960
            24  C2b C    37.3506  -14.8187
            25  O6a O    37.3564  -17.1788
            26  O6a O    39.3971  -16.0600
            27  C2b C    35.7114  -14.8245
            28  C6a C    35.0375  -16.0075
            29  O6a O    33.6707  -16.0075
            30  O6a O    35.7231  -17.1846
BOND        31
            1    12  14 1
            2     2   3 1
            3     9  15 1
            4     3   6 2
            5    15  16 1
            6     5   6 1
            7    15  17 1
            8     6   7 1
            9     7   8 1
            10    8   9 2
            11    9   5 1
            12    5   4 2
            13   16  18 2
            14   18  19 1
            15   19  20 2
            16   20  21 1
            17   21  22 2
            18   22  16 1
            19    8  10 1
            20    4   1 1
            21   10  11 1
            22   11  12 1
            23   12  13 1
            24    1   2 2
            25   23  24 1
            26   23  25 1
            27   23  26 2
            28   24  27 2
            29   27  28 1
            30   28  29 1
            31   28  30 2

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