KEGG   DRUG: D01358Help
Entry
D01358                      Drug                                   

Name
Mianserin hydrochloride (JAN/USAN);
Tetramide (TN)
Formula
C18H20N2. HCl
Exact mass
300.1393
Mol weight
300.8257
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Serotonin inhibitor;
Antihistaminic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Tetracyclic antidepressants
Target
5-HT1-receptor antagonist [HSA:3350 3351 3352 3354 3355] [KO:K04153];
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Structure map
Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01358  Mianserin hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
    alpha2-adrenergic receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
   Serotonin
    5-HT1-receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
    5-HT2-receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Mianserin
    D01358  Mianserin hydrochloride (JAN/USAN)
  CYP2D6
   Mianserin
    D01358  Mianserin hydrochloride (JAN/USAN)
  CYP3A4
   Mianserin
    D01358  Mianserin hydrochloride (JAN/USAN)
Neuropsychiatric agents [br08363.html]
 Antidepressants
  D01358
BRITE hierarchy
Other DBs
CAS: 
21535-47-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   X   Cl   21.7700  -20.6500
            2   C8y C    19.4600  -15.8900
            3   N1y N    18.5500  -16.9400
            4   C1y C    17.1500  -16.9400
            5   C8y C    16.3100  -15.8200
            6   C8y C    19.1800  -14.4900
            7   C8y C    16.6600  -14.4900
            8   C1x C    17.9200  -13.8600
            9   C8x C    15.6800  -13.5100
            10  C8x C    14.2800  -13.9300
            11  C8x C    14.0000  -15.2600
            12  C8x C    14.9800  -16.2400
            13  C8x C    20.7900  -16.3100
            14  C8x C    21.8400  -15.4000
            15  C8x C    21.5600  -14.0000
            16  C8x C    20.2300  -13.5800
            17  C1x C    16.4500  -18.1300
            18  N1y N    17.1500  -19.3900
            19  C1x C    18.5500  -19.3900
            20  C1x C    19.2500  -18.2000
            21  C1a C    16.4500  -20.5800
BOND        23
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     7   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    5  12 2
            13    2  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    6  16 2
            18    4  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22    3  20 1
            23   18  21 1

» Japanese version   » Back

DBGET integrated database retrieval system