KEGG   DRUG: Mianserin hydrochlorideHelp
Entry
D01358                      Drug                                   

Name
Mianserin hydrochloride (JAN/USAN);
Tetramide (TN)
Formula
C18H20N2. HCl
Exact mass
300.1393
Mol weight
300.8257
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01729  Tetracyclic antidepressant
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
Therapeutic category: 1179
ATC code: N06AX03
Chemical structure group: DG00951
Product (DG00951): D01358<JP>
Efficacy
Antidepressant
Comment
Tetracyclic antidepressants
Antihistaminic
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01358  Mianserin hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
    alpha2-adrenergic receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
   Histamine
    H1-receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
   Serotonin
    5-HT2-receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
    5-HT3-receptor
     Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN)
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01358
BRITE hierarchy
Other DBs
CAS: 21535-47-7
PubChem: 7848421
ChEBI: 31843
ChEMBL: CHEMBL544428
LigandBox: D01358
NIKKAJI: J342.139B
KCF data Show

ATOM        21
            1   X   Cl   21.7700  -20.6500
            2   C8y C    19.4600  -15.8900
            3   N1y N    18.5500  -16.9400
            4   C1y C    17.1500  -16.9400
            5   C8y C    16.3100  -15.8200
            6   C8y C    19.1800  -14.4900
            7   C8y C    16.6600  -14.4900
            8   C1x C    17.9200  -13.8600
            9   C8x C    15.6800  -13.5100
            10  C8x C    14.2800  -13.9300
            11  C8x C    14.0000  -15.2600
            12  C8x C    14.9800  -16.2400
            13  C8x C    20.7900  -16.3100
            14  C8x C    21.8400  -15.4000
            15  C8x C    21.5600  -14.0000
            16  C8x C    20.2300  -13.5800
            17  C1x C    16.4500  -18.1300
            18  N1y N    17.1500  -19.3900
            19  C1x C    18.5500  -19.3900
            20  C1x C    19.2500  -18.2000
            21  C1a C    16.4500  -20.5800
BOND        23
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     7   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    5  12 2
            13    2  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    6  16 2
            18    4  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22    3  20 1
            23   18  21 1

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