KEGG   DRUG: D01372Help
Entry
D01372                      Drug                                   
Name
Zopiclone (JAN/INN);
Amoban (TN);
Zopiclone (TN)
Formula
C17H17ClN6O3
Exact mass
388.1051
Mol weight
388.8083
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypnotic
Remark
Therapeutic category: 
ATC code: 
Comment
non-benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C8 [HSA:1558]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D01372  Zopiclone (JAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF01 Zopiclone
      D01372  Zopiclone (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Zopiclone [ATC:N05CF01]
      D01372  Zopiclone (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
43200-80-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C8x C    25.0643  -11.5583
            2   C8x C    25.0643  -12.9592
            3   N5x N    26.2775  -13.6596
            4   C8y C    27.4908  -12.9592
            5   C8y C    27.4908  -11.5583
            6   N5x N    26.2775  -10.8578
            7   C1y C    28.8230  -13.3920
            8   N1y N    29.6464  -12.2587
            9   C5x C    28.8230  -11.1254
            10  C8y C    31.0180  -12.2587
            11  N5x N    31.7185  -13.4719
            12  C8x C    33.1194  -13.4719
            13  C8y C    33.8198  -12.2587
            14  C8x C    33.1194  -11.0455
            15  C8x C    31.7185  -11.0455
            16  O5x O    29.2544   -9.7977
            17  X   Cl   35.2207  -12.2587
            18  O7a O    28.8230  -14.7929
            19  C7a C    30.0482  -15.5006
            20  N1y N    30.0478  -16.8816
            21  O6a O    31.2616  -14.8004
            22  C1x C    28.8266  -17.5862
            23  C1x C    28.8263  -18.9871
            24  N1y N    30.0393  -19.6878
            25  C1x C    31.2605  -18.9832
            26  C1x C    31.2609  -17.5823
            27  C1a C    30.0390  -21.0842
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    9  16 2
            19   13  17 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23    7  18 1
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   20  26 1
            30   24  27 1

» Japanese version   » Back
DBGET integrated database retrieval system