KEGG   DRUG: D01372Help
Entry
D01372                      Drug                                   

Name
Zopiclone (JAN/INN);
Amoban (TN);
Zopiclone (TN)
Formula
C17H17ClN6O3
Exact mass
388.1051
Mol weight
388.8083
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypnotic
Remark
Therapeutic category: 
ATC code: 
Comment
non-benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C8 [HSA:1558]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF01 Zopiclone
      D01372  Zopiclone (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D01372  Zopiclone (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor
     Zopiclone
      D01372  Zopiclone (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C8
   Zopiclone
    D01372  Zopiclone (JAN/INN)
  CYP3A4
   Zopiclone
    D01372  Zopiclone (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
43200-80-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C8x C    13.5800  -12.3200
            2   C8x C    13.5800  -13.7200
            3   N5x N    14.7700  -14.4200
            4   C8y C    16.0300  -13.7200
            5   C8y C    16.0300  -12.3200
            6   N5x N    14.7700  -11.6200
            7   C1y C    17.3600  -14.1400
            8   N1y N    18.2000  -13.0200
            9   C5x C    17.3600  -11.9000
            10  C8y C    19.5300  -13.0200
            11  N5x N    20.2300  -11.8300
            12  C8x C    21.6300  -11.8300
            13  C8y C    22.3300  -13.0200
            14  C8x C    21.6300  -14.2100
            15  C8x C    20.2300  -14.2100
            16  O5x O    17.7800  -10.5700
            17  X   Cl   23.7300  -13.0200
            18  O7a O    17.3600  -15.5400
            19  C7a C    18.5500  -16.2400
            20  N1y N    18.5500  -17.6400
            21  O6a O    19.8100  -15.5400
            22  C1x C    17.3600  -18.3400
            23  C1x C    17.3600  -19.7400
            24  N1y N    18.5500  -20.4400
            25  C1x C    19.8100  -19.7400
            26  C1x C    19.8100  -18.3400
            27  C1a C    18.5500  -21.8400
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    9  16 2
            19   13  17 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23    7  18 1
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   20  26 1
            30   24  27 1

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