KEGG   DRUG: D01385Help
Entry
D01385                      Drug                                   

Name
Ibudilast (JP16/INN);
Ketas (TN)
Formula
C14H18N2O
Exact mass
230.1419
Mol weight
230.3055
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
ATC code: 
Target
phosphodiesterase (PDE) III inhibitor [HSA:5139 5140] [KO:K13296];
phosphodiesterase (PDE) IV inhibitor [HSA:5141 5142 5143 5144] [KO:K01120];
cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist [HSA:10800] [KO:K04322];
prostaglandin I2 receptor agonist [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
    R03DC Leukotriene receptor antagonists
     R03DC04 Ibudilast
      D01385  Ibudilast (JP16/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01385  Ibudilast (JP16/INN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D01385  Ibudilast (JP16/INN)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01385  Ibudilast (JP16/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    prostaglandin I2 receptor
     Ibudilast
      D01385  Ibudilast (JP16/INN)
   Cysteinyl leukotriene
    cysteinyl leukotriene receptor 1
     Ibudilast
      D01385  Ibudilast (JP16/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01385  Ibudilast
BRITE hierarchy
Other DBs
CAS: 
50847-11-5
PubChem: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    30.7566  -13.8910
            2   C8x C    27.0075  -12.0480
            3   C8x C    27.0075  -13.4486
            4   C8x C    28.2235  -14.1489
            5   C8x C    28.2235  -11.3477
            6   N4y N    29.4322  -12.0480
            7   C8y C    29.4263  -13.4520
            8   C8y C    31.5895  -12.7592
            9   N5x N    30.7693  -11.6199
            10  C1c C    32.9902  -12.7663
            11  C1a C    33.6842  -13.9831
            12  C1a C    33.6968  -11.5570
            13  C5a C    30.7566  -15.2910
            14  O5a O    29.5382  -15.9946
            15  C1c C    31.9358  -15.9713
            16  C1a C    33.1409  -15.2749
            17  C1a C    31.9362  -17.3599
BOND        18
            1     1   8 1
            2     8   9 2
            3     9   6 1
            4     6   5 1
            5     8  10 1
            6     5   2 2
            7     2   3 1
            8     3   4 2
            9     4   7 1
            10    6   7 1
            11   10  11 1
            12    7   1 2
            13   10  12 1
            14    1  13 1
            15   13  14 2
            16   13  15 1
            17   15  16 1
            18   15  17 1

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