KEGG   DRUG: Isoproterenol hydrochlorideHelp
Entry
D01390                      Drug                                   

Name
Isoproterenol hydrochloride (USP);
dl-Isoprenaline hydrochloride (JAN);
Isuprel (TN);
Proternol-S (TN)
Product
Formula
C11H17NO3. HCl
Exact mass
247.0975
Mol weight
247.7185
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
 DG01592  COMT substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antivertigo, Cardiotonic, Bronchodilator, beta-Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA02 Isoprenaline
      D01390  Isoproterenol hydrochloride (USP)
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AB Non-selective beta-adrenoreceptor agonists
     R03AB02 Isoprenaline
      D01390  Isoproterenol hydrochloride (USP)
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CB Non-selective beta-adrenoreceptor agonists
     R03CB01 Isoprenaline
      D01390  Isoproterenol hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   133  Vertigo agents
    1339  Others
     D01390  Isoproterenol hydrochloride (USP); dl-Isoprenaline hydrochloride (JAN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D01390  Isoproterenol hydrochloride (USP); dl-Isoprenaline hydrochloride (JAN)
  22  Respiratory organ agents
   225  Bronchodilators
    2252  Isoprenalines
     D01390  Isoproterenol hydrochloride (USP); dl-Isoprenaline hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Isoprenaline
      D01390  Isoproterenol hydrochloride (USP)
    beta2-adrenergic receptor
     Isoprenaline
      D01390  Isoproterenol hydrochloride (USP)
    beta3-adrenergic receptor
     Isoprenaline
      D01390  Isoproterenol hydrochloride (USP)
Respiratory agents [br08372.html]
 Bronchodilator
  D01390
BRITE hierarchy
Other DBs
CAS: 
51-30-9
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   X   Cl   32.4563  -16.2547
            2   C8y C    22.3615  -15.8607
            3   C8x C    21.1737  -15.0920
            4   C8x C    22.3615  -17.2582
            5   C8y C    19.9159  -15.7908
            6   C8x C    21.1038  -17.8870
            7   C8y C    19.9159  -17.1184
            8   O1a O    18.7280  -15.0222
            9   O1a O    18.7280  -17.8172
            10  C1c C    23.6193  -15.1619
            11  C1b C    24.8072  -15.8607
            12  N1b N    25.9950  -15.1619
            13  C1c C    27.2528  -15.8607
            14  C1a C    28.4407  -15.1619
            15  O1a O    23.6193  -13.7644
            16  C1a C    27.2528  -17.2582
BOND        15
            1     2   3 1
            2     2   4 2
            3     3   5 2
            4     4   6 1
            5     5   7 1
            6     5   8 1
            7     7   9 1
            8     6   7 2
            9     2  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  15 1
            15   13  16 1

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