KEGG   DRUG: D01390Help
Entry
D01390                      Drug                                   

Name
dl-Isoprenaline hydrochloride (JAN);
Isoproterenol hydrochloride (USP);
Isuprel (TN);
Proternol-S (TN)
Product
Formula
C11H17NO3. HCl
Exact mass
247.0975
Mol weight
247.7185
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Bronchodilator [DS:H00079]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AB Non-selective beta-adrenoreceptor agonists
     R03AB02 Isoprenaline
      D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CB Non-selective beta-adrenoreceptor agonists
     R03CB01 Isoprenaline
      D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   133  Vertigo agents
    1339  Others
     D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
  22  Respiratory organ agents
   225  Bronchodilators
    2252  Isoprenalines
     D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Isoprenaline
      D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
    beta2-adrenergic receptor
     Isoprenaline
      D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
    beta3-adrenergic receptor
     Isoprenaline
      D01390  dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
51-30-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   X   Cl   32.4563  -16.2547
            2   C8y C    22.3615  -15.8607
            3   C8x C    21.1737  -15.0920
            4   C8x C    22.3615  -17.2582
            5   C8y C    19.9159  -15.7908
            6   C8x C    21.1038  -17.8870
            7   C8y C    19.9159  -17.1184
            8   O1a O    18.7280  -15.0222
            9   O1a O    18.7280  -17.8172
            10  C1c C    23.6193  -15.1619
            11  C1b C    24.8072  -15.8607
            12  N1b N    25.9950  -15.1619
            13  C1c C    27.2528  -15.8607
            14  C1a C    28.4407  -15.1619
            15  O1a O    23.6193  -13.7644
            16  C1a C    27.2528  -17.2582
BOND        15
            1     2   3 1
            2     2   4 2
            3     3   5 2
            4     4   6 1
            5     5   7 1
            6     5   8 1
            7     7   9 1
            8     6   7 2
            9     2  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  15 1
            15   13  16 1

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