KEGG   DRUG: D01408Help
Entry
D01408                      Drug                                   

Name
Flurazepam hydrochloride (JP16);
Flurazepam monohydrochloride;
Dalmate (TN)
Formula
C21H23ClFN3O. HCl
Exact mass
423.128
Mol weight
424.3392
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsants, Sedative-hypnotic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD01 Flurazepam
      D01408  Flurazepam hydrochloride (JP16)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01408  Flurazepam hydrochloride (JP16)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Flurazepam
      D01408  Flurazepam hydrochloride (JP16)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Flurazepam
    D01408  Flurazepam hydrochloride (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01408  Flurazepam hydrochloride
BRITE hierarchy
Other DBs
CAS: 
36105-20-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   X   Cl   36.6766  -12.5550
            2   C2y C    31.7800  -13.0200
            3   C8y C    30.9400  -11.9000
            4   C8y C    31.2900  -10.5000
            5   N1y N    32.5500   -9.9400
            6   N2x N    33.2500  -13.0200
            7   C5x C    33.8100  -10.5700
            8   C1x C    34.0900  -11.9700
            9   C8x C    30.3100   -9.5200
            10  C8x C    28.9800   -9.9400
            11  C8y C    28.6300  -11.2700
            12  C8x C    29.6100  -12.2500
            13  O5x O    34.8600   -9.6600
            14  X   Cl   27.2300  -11.6900
            15  C8y C    31.1500  -14.2800
            16  C8x C    29.7500  -14.2800
            17  C8x C    29.0500  -15.4700
            18  C8x C    29.7500  -16.6600
            19  C8x C    31.1500  -16.6600
            20  C8y C    31.8500  -15.4700
            21  X   F    33.3200  -15.4700
            22  C1b C    32.5500   -8.5400
            23  C1b C    33.7400   -7.9100
            24  N1c N    33.7400   -6.4400
            25  C1b C    35.0000   -5.7400
            26  C1b C    32.5500   -5.7400
            27  C1a C    31.3600   -6.4400
            28  C1a C    36.1900   -6.4400
BOND        29
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    7  13 2
            14   11  14 1
            15    2  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   15  20 2
            22   20  21 1
            23    5  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1
            28   26  27 1
            29   25  28 1

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