KEGG   DRUG: D01415Help
Entry
D01415                      Drug                                   

Name
Cefotiam hexetil hydrochloride (JP16);
CTM-HE;
Pansporin-T (TN)
Formula
C27H37N9O7S3. 2HCl
Exact mass
767.1512
Mol weight
768.7557
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Semisynthetic cephalosporin: intermediate spectrum cephalosporin
prodrug, active substance: Cefotiam [DR:D07648]
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
Drug interaction
Structure map
Cephalosporins - parenteral agents
Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC07 Cefotiam
      D01415  Cefotiam hexetil hydrochloride (JP16)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D01415  Cefotiam hexetil hydrochloride (JP16)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Cephems - Cephalosporins
     Cefotiam
      D01415  Cefotiam hexetil hydrochloride (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01415  Cefotiam hexetil hydrochloride
BRITE hierarchy
Other DBs
CAS: 
95789-30-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        48
            1   C1y C    26.1992  -13.1725
            2   N1y N    26.1992  -14.5495
            3   C2y C    27.3919  -15.2378
            4   C2y C    28.5843  -14.5495
            5   C1x C    28.5843  -13.1725
            6   S2x S    27.3919  -12.4840
            7   C1y C    24.8221  -13.1725
            8   C5x C    24.8221  -14.5495
            9   N1b N    23.6297  -12.4840
            10  C5a C    22.4369  -13.1725
            11  O5a O    22.4369  -14.5495
            12  O5x O    23.6297  -15.2378
            13  C1b C    21.2445  -12.4840
            14  C1b C    29.7951  -15.2488
            15  C8y C    20.0327  -13.1840
            16  S2a S    30.9926  -14.5578
            17  C8y C    32.1849  -15.2464
            18  N5x N    32.5850  -16.6308
            19  N5x N    33.9627  -16.6606
            20  N5x N    34.4167  -15.2906
            21  N4y N    33.3196  -14.4567
            22  C8x C    18.8966  -12.3839
            23  S2x S    17.7800  -13.2176
            24  C8y C    18.2276  -14.5369
            25  N5x N    19.6209  -14.5889
            26  C1b C    33.3507  -13.0409
            27  C1b C    34.5451  -12.3066
            28  N1c N    35.7526  -12.9597
            29  C1a C    36.9049  -12.2509
            30  C1a C    35.7924  -14.3526
            31  N1a N    17.3885  -15.6630
            32  C7a C    27.3919  -17.4647
            33  O6a O    26.1934  -18.1567
            34  O7a O    28.5974  -18.1608
            35  C1c C    28.5974  -19.5488
            36  C1a C    27.3806  -20.2515
            37  O7a O    29.7827  -20.2333
            38  C7a C    30.9616  -19.5525
            39  O7a O    32.1418  -20.2341
            40  C1y C    33.3213  -19.5530
            41  O6a O    30.9617  -18.1589
            42  C1x C    34.5013  -20.2343
            43  C1x C    35.7033  -19.5403
            44  C1x C    35.7034  -18.1523
            45  C1x C    34.5234  -17.4711
            46  C1x C    33.3214  -18.1650
            47  X   Cl   20.8705  -19.0297
            48  X   Cl   20.8705  -19.0297
BOND        50
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16   13  15 1
            17   14  16 1
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   17  21 1
            24   15  22 2
            25   22  23 1
            26   23  24 1
            27   24  25 2
            28   15  25 1
            29   21  26 1
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 1
            34   24  31 1
            35    3  32 1
            36   32  33 2
            37   32  34 1
            38   34  35 1
            39   35  36 1
            40   35  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   38  41 2
            45   40  42 1
            46   42  43 1
            47   43  44 1
            48   44  45 1
            49   45  46 1
            50   40  46 1
BRACKET     1    19.1800  -19.7400   19.1800  -18.3400
            1    21.5600  -18.3400   21.5600  -19.7400
            1  2
 ORIGINAL  1   48
 REPEAT    1   49

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