KEGG   DRUG: D01429Help
Entry
D01429                      Drug                                   

Name
Fosfluconazole (JAN/INN);
Prodif (TN)
Formula
C13H13F2N6O4P
Exact mass
386.0704
Mol weight
386.2507
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antifungal
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, acrive substance: Fluconazole [DR:D00322]
Target
sterol 14alpha-demethylase ihibitor [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC15 Fluconazole
      D01429  Fosfluconazole (JAN/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole derivatives
     J02AC01 Fluconazole
      D01429  Fosfluconazole (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D01429  Fosfluconazole (JAN/INN)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor
    Triazoles
     Fluconazole
      D01429  Fosfluconazole (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Fluconazole
    D01429  Fosfluconazole (JAN/INN)
  CYP2C19
   Fluconazole
    D01429  Fosfluconazole (JAN/INN)
  CYP3A4
   Fluconazole
    D01429  Fosfluconazole (JAN/INN)
 Inhbitors
  CYP2C19
   Fluconazole
    D01429  Fosfluconazole (JAN/INN)
  CYP3A
   Fluconazole
    D01429  Fosfluconazole (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
194798-83-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8x C    30.1700  -12.4600
            2   C8x C    30.1700  -13.8600
            3   C8y C    31.2900  -14.5600
            4   C8y C    32.4800  -13.8600
            5   C8x C    32.4800  -12.4600
            6   C8y C    31.2900  -11.7600
            7   X   F    31.2900  -10.4300
            8   X   F    33.7400  -14.5600
            9   C1d C    31.2900  -16.7300
            10  C1b C    30.1000  -17.4300
            11  C1b C    32.4800  -17.3600
            12  N4y N    28.9800  -16.7300
            13  N4y N    33.6700  -16.7300
            14  C8x C    28.9800  -15.3300
            15  C8x C    33.6700  -15.3300
            16  N5x N    27.6500  -14.9100
            17  C8x C    26.8100  -16.0300
            18  N5x N    27.6500  -17.1500
            19  N5x N    34.9300  -17.1500
            20  C8x C    35.7700  -16.0300
            21  N5x N    34.9300  -14.9100
            22  O2b O    31.2900  -18.0600
            23  P1b P    31.2900  -19.4600
            24  O1c O    31.2900  -20.7900
            25  O1c O    32.6900  -19.4600
            26  O1c O    29.9600  -19.4600
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     4   8 1
            9     3   9 1
            10    9  10 1
            11    9  11 1
            12   10  12 1
            13   11  13 1
            14   12  14 1
            15   13  15 1
            16   14  16 2
            17   16  17 1
            18   17  18 2
            19   12  18 1
            20   13  19 1
            21   19  20 2
            22   20  21 1
            23   15  21 2
            24    9  22 1
            25   22  23 1
            26   23  24 2
            27   23  25 1
            28   23  26 1

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