| Entry |
|
|---|
| Name |
Fosfluconazole (JAN/INN);
Prodif (TN)
|
|---|
| Formula |
C13H13F2N6O4P
|
|---|
| Exact mass |
386.0704
|
|---|
| Mol weight |
386.2507
|
|---|
| Structure |
     |
|---|
| Activity |
Antifungal
|
|---|
| Remark |
Therapeutic category: ATC code: |
|---|
| Comment |
prodrug of Fluconazole [DR: D00322]
|
|---|
| Target |
sterol 14alpha-demethylase ihibitor [KO: K05917] |
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP3A [KO: K07424]
 |
|---|
| Structure map |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D01429 Fosfluconazole (JAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AC Imidazole and triazole derivatives
D01AC15 Fluconazole
D01429 Fosfluconazole (JAN/INN)
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AC Triazole derivatives
J02AC01 Fluconazole
D01429 Fosfluconazole (JAN/INN)
Antiinfectives [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
sterol 14alpha-demethylase inhibitor [KO:K05917]
Triazoles
Fluconazole [ATC:D01AC15 J02AC01]
D01429 Fosfluconazole (JAN/INN)
 |
|---|
| Other DBs |
CAS: 194798-83-9 PubChem: DrugBank: LigandBox: NIKKAJI: |
|---|
| KCF data |
ATOM 26
1 C8x C 30.1700 -12.4600
2 C8x C 30.1700 -13.8600
3 C8y C 31.2900 -14.5600
4 C8y C 32.4800 -13.8600
5 C8x C 32.4800 -12.4600
6 C8y C 31.2900 -11.7600
7 X F 31.2900 -10.4300
8 X F 33.7400 -14.5600
9 C1d C 31.2900 -16.7300
10 C1b C 30.1000 -17.4300
11 C1b C 32.4800 -17.3600
12 N4y N 28.9800 -16.7300
13 N4y N 33.6700 -16.7300
14 C8x C 28.9800 -15.3300
15 C8x C 33.6700 -15.3300
16 N5x N 27.6500 -14.9100
17 C8x C 26.8100 -16.0300
18 N5x N 27.6500 -17.1500
19 N5x N 34.9300 -17.1500
20 C8x C 35.7700 -16.0300
21 N5x N 34.9300 -14.9100
22 O2b O 31.2900 -18.0600
23 P1b P 31.2900 -19.4600
24 O1c O 31.2900 -20.7900
25 O1c O 32.6900 -19.4600
26 O1c O 29.9600 -19.4600
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 4 8 1
9 3 9 1
10 9 10 1
11 9 11 1
12 10 12 1
13 11 13 1
14 12 14 1
15 13 15 1
16 14 16 2
17 16 17 1
18 17 18 2
19 12 18 1
20 13 19 1
21 19 20 2
22 20 21 1
23 15 21 2
24 9 22 1
25 22 23 1
26 23 24 2
27 23 25 1
28 23 26 1
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