KEGG   DRUG: D01455Help
Entry
D01455                      Drug                                   

Name
Cibenzoline succinate (JP16);
Cifenline succinate (USAN);
Cibenol (TN);
Cipralan (TN)
Formula
C18H18N2. C4H6O4
Exact mass
380.1736
Mol weight
380.437
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhytmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG07 Cibenzoline
      D01455  Cibenzoline succinate (JP16); Cifenline succinate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01455  Cibenzoline succinate (JP16); Cifenline succinate (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
    voltage-gated sodium channel (SCN2A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
    voltage-gated sodium channel (SCN3A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
    voltage-gated sodium channel (SCN4A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
    voltage-gated sodium channel (SCN5A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
    voltage-gated sodium channel (SCN8A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
    voltage-gated sodium channel (SCN9A)
     Cibenzoline
      D01455  Cifenline succinate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Cibenzoline
    D01455  Cibenzoline succinate (JP16); Cifenline succinate (USAN)
  CYP3A4
   Cibenzoline
    D01455  Cibenzoline succinate (JP16); Cifenline succinate (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01455  Cibenzoline succinate
  D01455  Cibenzoline succinate tablets
BRITE hierarchy
Other DBs
CAS: 
100678-32-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   O6a O    28.6206  -16.4110
            2   C6a C    29.8130  -17.1124
            3   C1b C    31.0755  -16.4110
            4   C1b C    32.2680  -17.1124
            5   C6a C    33.4604  -16.4110
            6   O6a O    34.7230  -17.1124
            7   O6a O    29.8130  -18.5153
            8   O6a O    33.4604  -15.0081
            9   C8x C    19.5021  -17.8163
            10  C8x C    19.5021  -19.2191
            11  C8x C    20.6946  -19.9206
            12  C8x C    21.9571  -19.2191
            13  C8y C    21.9571  -17.8163
            14  C8x C    20.6946  -17.1148
            15  C1z C    23.1496  -17.1120
            16  C1x C    22.4481  -15.9196
            17  C1y C    23.8510  -15.9196
            18  C2y C    25.0692  -15.2199
            19  N2x N    26.3859  -15.6250
            20  C1x C    27.1782  -14.4978
            21  C1x C    26.3510  -13.3960
            22  N1x N    25.0475  -13.8423
            23  C8x C    24.3420  -19.2191
            24  C8y C    24.3420  -17.8163
            25  C8x C    25.6046  -19.9206
            26  C8x C    26.7970  -19.2191
            27  C8x C    26.7970  -17.8163
            28  C8x C    25.6046  -17.1148
BOND        30
            1     2   7 2
            2     5   8 2
            3     3   4 1
            4     1   2 1
            5     4   5 1
            6     5   6 1
            7     2   3 1
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   16  17 1
            15   17  15 1
            16   15  16 1
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   18  22 1
            23   13  15 1
            24   23  24 1
            25   23  25 2
            26   25  26 1
            27   26  27 2
            28   27  28 1
            29   24  28 2
            30   15  24 1

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