KEGG   DRUG: D01460Help
Entry
D01460                      Drug                                   

Name
Homochlorcyclizine hydrochloride (JP16);
Homochlorcyclizine dihydrochloride;
SA 97 dihydrochloride;
Homoclomin (TN)
Formula
C19H23ClN2. 2HCl
Exact mass
386.1083
Mol weight
387.7742
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist
Remark
Therapeutic category: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D01460  Homochlorcyclizine hydrochloride (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Homochlorcyclizine
      D01460  Homochlorcyclizine hydrochloride (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01460  Homochlorcyclizine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
1982-36-1
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   30.8000  -16.9400
            2   C1x C    21.5600  -14.8400
            3   C1x C    21.4200  -13.5100
            4   C1x C    22.3300  -12.3900
            5   N1y N    23.8000  -12.6000
            6   N1y N    22.7500  -15.6100
            7   C1x C    24.5000  -13.7200
            8   C1x C    24.0800  -15.1200
            9   C1a C    24.5000  -11.4100
            10  C8y C    21.4900  -17.6400
            11  C1c C    22.7500  -17.0100
            12  C8y C    24.0100  -17.7100
            13  C8x C    24.0100  -19.1800
            14  C8x C    25.1300  -19.8800
            15  C8y C    26.3900  -19.1800
            16  C8x C    26.3900  -17.7800
            17  C8x C    25.2000  -17.0800
            18  C8x C    20.3000  -16.9400
            19  C8x C    19.1100  -17.6400
            20  C8x C    19.1100  -18.9700
            21  C8x C    20.3000  -19.6700
            22  C8x C    21.4900  -19.0400
            23  X   Cl   27.5800  -19.9500
            24  X   Cl   30.8000  -16.9400
BOND        24
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     5   9 1
            9    10  11 1
            10    6  11 1
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   15  16 1
            16   16  17 2
            17   12  17 1
            18   10  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   10  22 1
            24   15  23 1
BRACKET     1    29.2600  -17.7800   29.2600  -16.1000
            1    31.7100  -16.1000   31.7100  -17.7800
            1  2
 ORIGINAL  1    1
 REPEAT    1   24

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