KEGG   DRUG: D01467Help
Entry
D01467                      Drug                                   

Name
Roxatidine acetate hydrochloride (JP16/USAN);
Altat (TN)
Formula
C19H28N2O4. HCl
Exact mass
384.1816
Mol weight
384.8976
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiulcerative
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
H2-receptor antagonist [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA06 Roxatidine
      D01467  Roxatidine acetate hydrochloride (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D01467  Roxatidine acetate hydrochloride (JP16/USAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D01467  Roxatidine acetate hydrochloride (JP16/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 1
  Inorganic and organic chemicals
   Roxatidine acetate hydrochloride
    D01467  Roxatidine acetate hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor
     Roxatidine
      D01467  Roxatidine acetate hydrochloride (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01467  Roxatidine acetate hydrochloride
  D01467  Roxatidine acetate hydrochloride extended-release capsules
  D01467  Roxatidine acetate hydrochloride extended-release tablets
  D01467  Roxatidine acetate hydrochloride for injection
BRITE hierarchy
Other DBs
CAS: 
93793-83-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   N1b N    27.4400  -22.4000
            2   C8x C    18.9700  -20.3000
            3   C8y C    18.9700  -21.7000
            4   C8x C    20.2300  -22.4000
            5   C8y C    21.4200  -21.7000
            6   C8x C    21.4200  -20.3000
            7   C8x C    20.2300  -19.6000
            8   O2a O    22.6800  -22.4000
            9   C1b C    23.8700  -21.7000
            10  C1b C    25.0600  -22.4000
            11  C1b C    26.1800  -21.7000
            12  C1b C    17.7800  -22.4000
            13  N1y N    16.5900  -21.7000
            14  C1x C    16.5900  -20.3000
            15  C1x C    15.4000  -19.6000
            16  C1x C    14.1400  -20.3000
            17  C1x C    14.1400  -21.7000
            18  C1x C    15.3300  -22.4000
            19  C5a C    28.6300  -21.7000
            20  C1b C    29.8200  -22.4000
            21  O7a O    31.0100  -21.7000
            22  C7a C    32.2000  -22.4000
            23  C1a C    33.4600  -21.7000
            24  O5a O    28.6300  -20.3000
            25  O6a O    32.2000  -23.8000
            26  X   Cl   30.1700  -25.4800
BOND        26
            1     6   7 2
            2     7   2 1
            3    13  18 1
            4    14  15 1
            5    15  16 1
            6    16  17 1
            7    17  18 1
            8     8   9 1
            9     9  10 1
            10    2   3 2
            11   10  11 1
            12   11   1 1
            13    8   5 1
            14    1  19 1
            15   19  20 1
            16    3   4 1
            17   20  21 1
            18    3  12 1
            19   21  22 1
            20    4   5 2
            21   22  23 1
            22   12  13 1
            23   19  24 2
            24   13  14 1
            25   22  25 2
            26    5   6 1

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