KEGG   DRUG: D01469Help
Entry
D01469                      Drug                                   

Name
Amosulalol hydrochloride (JP16);
Lowgan (TN)
Formula
C18H24N2O5S. HCl
Exact mass
416.1173
Mol weight
416.9195
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertansive;
alfa-Adrenergic blocking;
beta-Adrenergic blocking
Remark
Therapeutic category: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
alpha-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01469  Amosulalol hydrochloride (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Amosulalol
      D01469  Amosulalol hydrochloride (JP16)
    beta1-adrenergic receptor
     Amosulalol
      D01469  Amosulalol hydrochloride (JP16)
    beta2-adrenergic receptor
     Amosulalol
      D01469  Amosulalol hydrochloride (JP16)
    beta3-adrenergic receptor
     Amosulalol
      D01469  Amosulalol hydrochloride (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01469  Amosulalol hydrochloride
  D01469  Amosulalol hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 
93633-92-2
PubChem: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C     8.8900  -28.7000
            2   C8x C     8.8900  -30.1000
            3   C8x C    10.1024  -30.8000
            4   C8y C    11.3149  -30.1000
            5   C8x C    11.3149  -28.7000
            6   C8y C    10.1024  -28.0000
            7   C1a C     7.6776  -28.0000
            8   S4a S    10.1024  -26.6002
            9   N1a N    10.1024  -25.2002
            10  O3c O     8.6800  -26.6002
            11  O3c O    11.4800  -26.6002
            12  C1c C    12.5460  -30.8110
            13  C1b C    13.7512  -30.1153
            14  O1a O    12.5457  -32.1999
            15  N1b N    14.9335  -30.7981
            16  C1b C    16.1275  -30.1088
            17  C1b C    17.3154  -30.7948
            18  O2a O    18.5065  -30.1071
            19  C8y C    19.6959  -30.7939
            20  C8y C    19.6959  -32.1998
            21  C8x C    20.9084  -32.8998
            22  C8x C    22.1208  -32.1998
            23  C8x C    22.1208  -30.7939
            24  C8x C    20.9084  -30.0939
            25  O2a O    18.4641  -32.9112
            26  C1a C    17.2588  -32.2154
            27  X   Cl   24.6400  -31.5000
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     6   8 1
            9     8   9 1
            10    8  10 2
            11    8  11 2
            12    4  12 1
            13   12  13 1
            14   12  14 1
            15   13  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   19  24 1
            26   20  25 1
            27   25  26 1

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