KEGG   DRUG: D01477Help
Entry
D01477                      Drug                                   

Name
Opipramol hydrochloride (JAN/USAN);
Insidon (TN)
Formula
C23H29N3O. 2HCl
Exact mass
435.1844
Mol weight
436.4177
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant;
Antipsychotic
Remark
ATC code: 
Drug group: 
Target
dopamine D2 receptor antagonist [HSA:1813] [KO:K04145];
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
sigma-1 receptor agonist [HSA:10280]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA05 Opipramol
      D01477  Opipramol hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Opipramol
      D01477  Opipramol hydrochloride (JAN/USAN)
   Histamine
    H1-receptor
     Opipramol
      D01477  Opipramol hydrochloride (JAN/USAN)
   Serotonin
    5-HT2-receptor
     Opipramol
      D01477  Opipramol hydrochloride (JAN/USAN)
   Opioid
    sigma1-opioid receptor
     Opipramol
      D01477  Opipramol hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
909-39-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C2x C    13.6952  -13.2773
            2   C8y C    12.8508  -12.1647
            3   C8y C    13.1869  -10.8042
            4   N1y N    14.4514  -10.2245
            5   C2x C    15.1048  -13.3026
            6   C8y C    15.7083  -10.8485
            7   C8y C    15.9956  -12.2210
            8   C8x C    12.1770   -9.8331
            9   C8x C    10.8314  -10.2223
            10  C8x C    10.4953  -11.5828
            11  C8x C    11.5051  -12.5536
            12  C8x C    17.3304  -12.6593
            13  C8x C    18.3775  -11.7223
            14  C8x C    18.0904  -10.3498
            15  C8x C    16.7553   -9.9115
            16  C1b C    14.4031   -8.8458
            17  C1b C    15.6304   -8.1628
            18  C1b C    16.8020   -8.8642
            19  N1y N    18.0275   -8.1823
            20  C1x C    19.2559   -8.9179
            21  C1x C    20.4794   -8.2374
            22  N1y N    20.5018   -6.8376
            23  C1x C    19.2734   -6.1019
            24  C1x C    18.0499   -6.7824
            25  C1b C    21.7219   -6.1590
            26  C1b C    22.9071   -6.8691
            27  O1a O    24.1214   -6.1939
            28  X   Cl   23.1726  -11.1629
            29  X   Cl   23.1726  -11.1629
BOND        30
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1
            29   25  26 1
            30   26  27 1
BRACKET     1    21.4900  -11.9700   21.4900  -10.2900
            1    24.0800  -10.2900   24.0800  -11.9700
            1  2
 ORIGINAL  1   28
 REPEAT    1   29

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