KEGG   DRUG: D01482Help
Entry
D01482                      Drug                                   

Name
Pipamperone hydrochloride (JAN)
Formula
C21H30FN3O2. 2HCl
Exact mass
447.1856
Mol weight
448.4021
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Therapeutic category: 
ATC code: 
Comment
Butyrophenone derivatives
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Interaction
Drug interaction
Structure map
Butyrophenones
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01482  Pipamperone hydrochloride (JAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD05 Pipamperone
      D01482  Pipamperone hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Pipamperone [ATC:N05AD05]
      D01482  Pipamperone hydrochloride (JAN)
   Serotonin
    5-HT2A-receptor [HSA:3356] [KO:K04157]
     Pipamperone [ATC:N05AD05]
      D01482  Pipamperone hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
2448-68-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1z C    36.3403  -17.0162
            2   C1x C    35.1498  -16.3160
            3   C1x C    33.8893  -17.0162
            4   N1y N    33.8893  -18.4168
            5   C1x C    35.1498  -19.1171
            6   C1x C    36.3403  -18.4168
            7   C1b C    32.6989  -19.1171
            8   C1b C    31.5084  -18.4168
            9   C1b C    30.2479  -19.1171
            10  C5a C    29.0574  -18.4168
            11  C8y C    27.8670  -19.1171
            12  O5a O    29.0574  -17.0162
            13  C8x C    26.6765  -18.4168
            14  C8x C    25.4160  -19.1171
            15  C8y C    25.4160  -20.5176
            16  C8x C    26.6765  -21.2179
            17  C8x C    27.8670  -20.5176
            18  X   F    24.2256  -21.1478
            19  N1y N    37.5307  -16.3160
            20  C1x C    38.7912  -17.0162
            21  C1x C    39.9817  -16.3160
            22  C1x C    39.9817  -14.9154
            23  C1x C    38.7912  -14.2152
            24  C1x C    37.5307  -14.9154
            25  C5a C    37.0405  -18.2067
            26  N1a N    38.4411  -18.2067
            27  O5a O    36.3403  -19.3972
            28  X   Cl   38.2200  -21.1400
            29  X   Cl   38.2200  -21.1400
BOND        29
            1     6   1 1
            2     4   7 1
            3    11  13 2
            4    13  14 1
            5    14  15 2
            6    15  16 1
            7    16  17 2
            8    17  11 1
            9    15  18 1
            10    7   8 1
            11    1  19 1
            12    8   9 1
            13    1   2 1
            14    9  10 1
            15    2   3 1
            16   19  20 1
            17   20  21 1
            18   21  22 1
            19   22  23 1
            20   23  24 1
            21   24  19 1
            22   10  11 1
            23    3   4 1
            24   10  12 2
            25    4   5 1
            26    5   6 1
            27   25  26 1
            28   25   1 1
            29   25  27 2
BRACKET     1    36.4700  -22.0500   36.4700  -20.3700
            1    39.2000  -20.3700   39.2000  -22.0500
            1  2
 ORIGINAL  1   28
 REPEAT    1   29

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