KEGG   DRUG: Pipamperone hydrochlorideHelp
Entry
D01482                      Drug                                   

Name
Pipamperone hydrochloride (JAN)
Formula
C21H30FN3O2. 2HCl
Exact mass
447.1856
Mol weight
448.4021
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01940  Butyrophenone derivative
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
Therapeutic category: 1179
ATC code: N05AD05
Chemical structure group: DG00889
Product (DG00889): D01482<JP>
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
Comment
Butyrophenone derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07031  Antipsychotics - butyrophenones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD05 Pipamperone
      D01482  Pipamperone hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01482  Pipamperone hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D01482  Pipamperone hydrochloride (JAN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01482
BRITE hierarchy
Other DBs
CAS: 2448-68-2
PubChem: 7848545
ChEBI: 32004
ChEMBL: CHEMBL2361301
LigandBox: D01482
NIKKAJI: J2.210.650C
KCF data Show

ATOM        29
            1   C1z C    36.3403  -17.0162
            2   C1x C    35.1498  -16.3160
            3   C1x C    33.8893  -17.0162
            4   N1y N    33.8893  -18.4168
            5   C1x C    35.1498  -19.1171
            6   C1x C    36.3403  -18.4168
            7   C1b C    32.6989  -19.1171
            8   C1b C    31.5084  -18.4168
            9   C1b C    30.2479  -19.1171
            10  C5a C    29.0574  -18.4168
            11  C8y C    27.8670  -19.1171
            12  O5a O    29.0574  -17.0162
            13  C8x C    26.6765  -18.4168
            14  C8x C    25.4160  -19.1171
            15  C8y C    25.4160  -20.5176
            16  C8x C    26.6765  -21.2179
            17  C8x C    27.8670  -20.5176
            18  X   F    24.2256  -21.1478
            19  N1y N    37.5307  -16.3160
            20  C1x C    38.7912  -17.0162
            21  C1x C    39.9817  -16.3160
            22  C1x C    39.9817  -14.9154
            23  C1x C    38.7912  -14.2152
            24  C1x C    37.5307  -14.9154
            25  C5a C    37.0405  -18.2067
            26  N1a N    38.4411  -18.2067
            27  O5a O    36.3403  -19.3972
            28  X   Cl   38.2200  -21.1400
            29  X   Cl   38.2200  -21.1400
BOND        29
            1     6   1 1
            2     4   7 1
            3    11  13 2
            4    13  14 1
            5    14  15 2
            6    15  16 1
            7    16  17 2
            8    17  11 1
            9    15  18 1
            10    7   8 1
            11    1  19 1
            12    8   9 1
            13    1   2 1
            14    9  10 1
            15    2   3 1
            16   19  20 1
            17   20  21 1
            18   21  22 1
            19   22  23 1
            20   23  24 1
            21   24  19 1
            22   10  11 1
            23    3   4 1
            24   10  12 2
            25    4   5 1
            26    5   6 1
            27   25  26 1
            28   25   1 1
            29   25  27 2
BRACKET     1    36.4700  -22.0500   36.4700  -20.3700
            1    39.2000  -20.3700   39.2000  -22.0500
            1  2
 ORIGINAL  1   28
 REPEAT    1   29

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