KEGG   DRUG: Bufetolol hydrochlorideHelp
Entry
D01504                      Drug                                   

Name
Bufetolol hydrochloride (JP17);
Adobiol (TN)
Formula
C18H29NO4. HCl
Exact mass
359.1863
Mol weight
359.8881
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Remark
Therapeutic category: 
Activity
Antiarrhythmic, Vasodilator, beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
beta1-adrenergic receptor [HSA:153] [KO:K04141];
beta2-adrenergic receptor [HSA:154] [KO:K04142];
beta3-adrenergic receptor [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D01504  Bufetolol hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Bufetolol
      D01504  Bufetolol hydrochloride (JP17)
    beta2-adrenergic receptor
     Bufetolol
      D01504  Bufetolol hydrochloride (JP17)
    beta3-adrenergic receptor
     Bufetolol
      D01504  Bufetolol hydrochloride (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01504  Bufetolol hydrochloride
BRITE hierarchy
Other DBs
CAS: 
35108-88-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   24.7800  -25.8300
            2   C1d C    24.1500  -21.1400
            3   C1a C    25.3624  -21.8400
            4   N1b N    22.9376  -21.8400
            5   C1b C    21.7421  -21.1496
            6   C1c C    20.5547  -21.8351
            7   C1b C    19.3635  -21.1471
            8   O1a O    20.5545  -23.2398
            9   O2a O    18.1740  -21.8338
            10  C8y C    18.1740  -23.2338
            11  C8y C    16.9786  -23.9242
            12  C8x C    16.9789  -25.3242
            13  C8x C    18.1914  -26.0240
            14  C8x C    19.3868  -25.3336
            15  C8x C    19.3866  -23.9336
            16  O2a O    15.7964  -23.2420
            17  C1b C    14.6027  -23.9316
            18  C1y C    13.4143  -23.2457
            19  O2x O    13.4055  -21.8404
            20  C1x C    12.0688  -21.4150
            21  C1x C    11.2511  -22.5547
            22  C1x C    12.0824  -23.6846
            23  C1a C    24.1500  -19.7400
            24  C1a C    25.3624  -20.4400
BOND        24
            1     2   3 1
            2     2   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     6   8 1
            7     7   9 1
            8     9  10 1
            9    10  11 2
            10   11  12 1
            11   12  13 2
            12   13  14 1
            13   14  15 2
            14   10  15 1
            15   11  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   18  22 1
            23    2  23 1
            24    2  24 1

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