KEGG   DRUG: D01514Help
Entry
D01514                      Drug                                   

Name
Etizolam (JP16/INN);
Etizolam fine granules (JP16);
Etizolam tablets (JP16);
Sedekopan (TN)
Formula
C17H15ClN4S
Exact mass
342.0706
Mol weight
342.8458
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Minor tranquilizer
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Thienodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Anxiolytics
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA19 Etizolam
      D01514  Etizolam (JP16/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01514  Etizolam (JP16/INN); Etizolam fine granules (JP16); Etizolam tablets (JP16)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Etizolam
      D01514  Etizolam (JP16/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Etizolam
    D01514  Etizolam (JP16/INN)
  CYP3A4
   Etizolam
    D01514  Etizolam (JP16/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01514  Etizolam
  D01514  Etizolam fine granules
  D01514  Etizolam tablets
BRITE hierarchy
Other DBs
CAS: 
40054-69-1
PubChem: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C2y C    32.3910  -16.5222
            2   C8y C    31.5532  -15.4102
            3   C8y C    31.8931  -14.0554
            4   N4y N    33.1554  -13.4822
            5   N2x N    33.7958  -16.5524
            6   C8y C    34.4061  -14.1085
            7   C1x C    34.6877  -15.4776
            8   S2x S    30.7095  -13.3135
            9   C8y C    29.6383  -14.2100
            10  C8x C    30.1596  -15.3659
            11  C8y C    31.6701  -17.7110
            12  C8x C    30.2798  -17.7110
            13  C8x C    29.5847  -18.9150
            14  C8x C    30.2798  -20.1191
            15  C8x C    31.6701  -20.1191
            16  C8y C    32.3653  -18.9150
            17  X   Cl   33.7695  -18.9151
            18  C1b C    28.4343  -13.5148
            19  C1a C    27.2318  -14.2091
            20  C8y C    33.1554  -12.0219
            21  N5x N    35.3883  -13.1125
            22  N5x N    34.7447  -11.8007
            23  C1a C    32.1002  -11.1732
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    1  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   11  16 2
            19   16  17 1
            20    9  18 1
            21   18  19 1
            22    4  20 1
            23    6  21 2
            24   21  22 1
            25   22  20 2
            26   20  23 1

» Japanese version   » Back

DBGET integrated database retrieval system