KEGG   DRUG: D01531Help
Entry
D01531                      Drug                                   

Name
Pipemidic acid hydrate (JP16);
PPA;
Karunomazin (TN)
Formula
C14H17N5O3. 3H2O
Exact mass
357.1648
Mol weight
357.3623
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MB Other quinolones
     J01MB04 Pipemidic acid
      D01531  Pipemidic acid hydrate (JP16)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D01531  Pipemidic acid hydrate (JP16)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Other quinolones
     Pipemidic acid
      D01531  Pipemidic acid hydrate (JP16)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP1A2
   Pipemidic acid
    D01531  Pipemidic acid hydrate (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01531  Pipemidic acid hydrate
BRITE hierarchy
Other DBs
CAS: 
72571-82-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   N5x N    19.7420  -18.1466
            2   C8y C    19.7420  -19.5478
            3   N5x N    20.9525  -20.2450
            4   C8x C    20.9525  -17.4423
            5   C8y C    22.1629  -18.1466
            6   C8y C    22.1570  -19.5478
            7   N4y N    23.3685  -20.2503
            8   C8x C    24.5860  -19.5582
            9   C8y C    24.5921  -18.1569
            10  C8y C    23.3805  -17.4476
            11  O5x O    23.3864  -16.0461
            12  C6a C    25.8095  -17.4579
            13  O6a O    27.0211  -18.1672
            14  O6a O    25.8156  -16.0564
            15  N1y N    18.5279  -20.2457
            16  C1b C    23.3626  -21.6446
            17  C1a C    22.1521  -22.3365
            18  C1x C    17.3193  -19.5396
            19  C1x C    16.1051  -20.2372
            20  N1x N    16.1024  -21.6377
            21  C1x C    17.3137  -22.3404
            22  C1x C    18.5279  -21.6426
            23  O0  O    31.7128  -19.3648
            24  O0  O    31.7128  -19.3648
            25  O0  O    31.7128  -19.3648
BOND        24
            1     9  12 1
            2    12  13 1
            3     1   2 1
            4    12  14 2
            5     2   3 2
            6     2  15 1
            7     3   6 1
            8     7  16 1
            9     5   4 1
            10   16  17 1
            11    5   6 2
            12    6   7 1
            13    7   8 1
            14    8   9 2
            15    9  10 1
            16   15  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  15 1
            22   10   5 1
            23    4   1 2
            24   10  11 2
BRACKET     1    29.8900  -20.4400   29.8900  -18.3400
            1    32.3400  -18.3400   32.3400  -20.4400
            1  3
 ORIGINAL  1   23
 REPEAT    1   24  25

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