KEGG   DRUG: D01548Help
Entry
D01548                      Drug                                   

Name
Mosapramine hydrochloride (JAN);
Cremin (TN)
Formula
C28H35ClN4O. 2HCl
Exact mass
550.2033
Mol weight
551.9786
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic
Remark
Therapeutic category: 
ATC code: 
Comment
Iminodibenzyl derivatives
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Dopamine receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01548  Mosapramine hydrochloride (JAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX10 Mosapramine
      D01548  Mosapramine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Mosapramine [ATC:N05AX10]
      D01548  Mosapramine hydrochloride (JAN)
   Serotonin
    5-HT2A-receptor [HSA:3356] [KO:K04157]
     Mosapramine [ATC:N05AX10]
      D01548  Mosapramine hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
98043-60-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C1x C    29.0129  -21.5541
            2   C8y C    28.1757  -20.4379
            3   C8y C    28.5246  -19.1125
            4   N1y N    29.7802  -18.5544
            5   C1x C    30.4080  -21.5541
            6   C8y C    31.0359  -19.1823
            7   C8y C    31.3149  -20.5077
            8   C8x C    27.4782  -18.1359
            9   C8x C    26.1528  -18.5544
            10  C8y C    25.8040  -19.8798
            11  C8x C    26.8504  -20.8565
            12  C8x C    32.6404  -20.9262
            13  C8x C    33.6866  -20.0193
            14  C8x C    33.4076  -18.6241
            15  C8x C    32.0823  -18.2056
            16  X   Cl   24.4786  -20.2984
            17  C1b C    29.7419  -17.1597
            18  C1b C    30.9412  -16.5028
            19  C1b C    32.1643  -17.2457
            20  N1y N    33.3850  -16.5768
            21  C1x C    34.6047  -17.3173
            22  C1x C    35.8281  -16.6466
            23  C1z C    35.8589  -15.2518
            24  C1x C    34.6391  -14.5112
            25  C1x C    33.4158  -15.1818
            26  N1y N    36.9217  -16.1774
            27  C1y C    38.1302  -15.4533
            28  N1x N    37.8152  -14.0801
            29  C5x C    36.4119  -13.9555
            30  C1x C    36.8745  -17.5860
            31  C1x C    38.1057  -18.2705
            32  C1x C    39.3143  -17.5466
            33  C1x C    39.3615  -16.1379
            34  O5x O    35.6977  -12.7628
            35  X   Cl   38.3606  -20.5174
            36  X   Cl   38.3606  -20.5174
BOND        39
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18   10  16 1
            19    4  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   20  25 1
            29   23  26 1
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   23  29 1
            34   26  30 1
            35   30  31 1
            36   31  32 1
            37   32  33 1
            38   27  33 1
            39   29  34 2
BRACKET     1    36.6800  -21.1400   36.6800  -19.8100
            1    39.0600  -19.8100   39.0600  -21.1400
            1  2
 ORIGINAL  1   35
 REPEAT    1   36

» Japanese version   » Back

DBGET integrated database retrieval system