KEGG   DRUG: Manidipine hydrochlorideHelp
Entry
D01553                      Drug                                   

Name
Manidipine hydrochloride (JP17);
Manidipine dihydrochloride;
Calslot (TN)
Formula
C35H38N4O6. 2HCl
Exact mass
682.2325
Mol weight
683.6213
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, Vasodilator, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA11 Manidipine
      D01553  Manidipine hydrochloride (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01553  Manidipine hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Manidipine
      D01553  Manidipine hydrochloride (JP17)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Manidipine
    D01553  Manidipine hydrochloride (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01553  Manidipine hydrochloride
  D01553  Manidipine hydrochloride tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01553
BRITE hierarchy
Other DBs
CAS: 
89226-75-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        47
            1   C8x C    24.4276  -18.8971
            2   C8x C    24.4276  -17.4973
            3   C8y C    25.6874  -16.7974
            4   C8x C    26.8772  -17.4973
            5   C8y C    26.8772  -18.8971
            6   C8x C    25.6874  -19.5970
            7   C1y C    25.6874  -15.3976
            8   C2y C    24.4276  -14.6978
            9   C2y C    24.4276  -13.2980
            10  N1x N    25.6874  -12.5981
            11  C2y C    26.8772  -13.2980
            12  C2y C    26.8772  -14.6978
            13  C7a C    28.0670  -15.3976
            14  O7a O    29.3268  -14.6978
            15  C1b C    30.5166  -15.3976
            16  C1b C    31.7065  -14.6978
            17  N1y N    32.9662  -15.3976
            18  C1x C    34.1561  -14.6978
            19  C1x C    35.3459  -15.3976
            20  N1y N    35.3459  -16.7974
            21  C1x C    34.1561  -17.4973
            22  C1x C    32.9662  -16.7974
            23  O6a O    28.0670  -16.7974
            24  C1c C    36.6057  -17.4973
            25  C8y C    37.7955  -16.7974
            26  C8y C    36.6057  -18.8971
            27  C8x C    37.7955  -19.5970
            28  C8x C    37.7955  -20.9967
            29  C8x C    36.5357  -21.6966
            30  C8x C    35.3459  -20.9967
            31  C8x C    35.3459  -19.5970
            32  C8x C    37.7955  -15.3976
            33  C8x C    38.9853  -14.6978
            34  C8x C    40.1751  -15.3976
            35  C8x C    40.1751  -16.7974
            36  C8x C    38.9853  -17.4973
            37  C1a C    28.0670  -12.5981
            38  C1a C    23.2378  -12.5981
            39  C7a C    23.2378  -15.3976
            40  O6a O    23.2378  -16.7974
            41  O7a O    22.0480  -14.6978
            42  C1a C    20.7882  -15.3976
            43  N2b N    28.0670  -19.5970 #+
            44  O3a O    29.3268  -18.8971
            45  O3a O    28.0670  -20.9967 #-
            46  X   Cl   43.3945  -17.3573
            47  X   Cl   43.3945  -17.3573
BOND        49
            1    21  22 1
            2    22  17 1
            3     7   8 1
            4    13  23 2
            5     8   9 2
            6    20  24 1
            7     9  10 1
            8    24  25 1
            9    10  11 1
            10   24  26 1
            11   11  12 2
            12   12   7 1
            13    4   5 1
            14   12  13 1
            15    5   6 2
            16   26  27 2
            17   27  28 1
            18   28  29 2
            19   29  30 1
            20   30  31 2
            21   31  26 1
            22   13  14 1
            23    6   1 1
            24   14  15 1
            25   15  16 1
            26   25  32 2
            27   32  33 1
            28   33  34 2
            29   34  35 1
            30   35  36 2
            31   36  25 1
            32    3   7 1
            33   11  37 1
            34   16  17 1
            35    9  38 1
            36    8  39 1
            37   39  40 2
            38    1   2 2
            39   39  41 1
            40    2   3 1
            41   41  42 1
            42    3   4 2
            43    5  43 1
            44   17  18 1
            45   43  44 2
            46   18  19 1
            47   43  45 1
            48   19  20 1
            49   20  21 1
BRACKET     1    41.9300  -18.1300   41.9300  -16.5900
            1    44.1700  -16.5900   44.1700  -18.1300
            1  2
 ORIGINAL  1   46
 REPEAT    1   47

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