KEGG   DRUG: D01554Help
Entry
D01554                      Drug                                   

Name
Pilsicainide hydrochloride hydrate (JP16);
Pilsicainide hydrochloride;
Pilsicainide hydrochloride capsules (JP16);
SUN 1165 (TN);
Sunrythm (TN)
Formula
(C17H24N2O. HCl)2. H2O
Exact mass
634.3416
Mol weight
635.7077
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
Comment
Class I antiarrhythmic agent (Ic)
Target
voltage-gated potassium channel (KCNA1) blocker [HSA:3736] [KO:K04874];
voltage-gated potassium channel (KCNA2) blocker [HSA:3737] [KO:K04875];
voltage-gated potassium channel (KCNA5) blocker [HSA:3741] [KO:K04878];
voltage-gated potassium channel (KCNA7) blocker [HSA:3743] [KO:K04880];
voltage-gated potassium channel (KCNC1) blocker [HSA:3746] [KO:K04887];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01554  Pilsicainide hydrochloride hydrate (JP16); Pilsicainide hydrochloride capsules (JP16)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN2A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN3A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN4A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN5A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN8A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated sodium channel (SCN9A)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA1)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated potassium channel (KCNA2)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated potassium channel (KCNA5)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
    voltage-gated potassium channel (KCNA7)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
   K+ channel, KCNC, Kv3.x (Shaw)
    voltage-gated potassium channel (KCNC1)
     Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate (JAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01554  Pilsicainide hydrochloride hydrate
  D01554  Pilsicainide hydrochloride capsules
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        43
            1   C8y C    23.4457  -28.8068
            2   C8y C    24.6550  -29.5069
            3   C8x C    25.8660  -28.8097
            4   C8x C    25.8677  -27.4122
            5   C8x C    24.6583  -26.7120
            6   C8y C    23.4474  -27.4093
            7   N1y N    19.8148  -32.3137
            8   C1z C    19.8089  -30.9148
            9   C1x C    21.1432  -32.7408
            10  C1x C    18.4804  -32.7525
            11  C1x C    21.1374  -30.4759
            12  C1x C    18.4745  -30.4817
            13  C1x C    21.9626  -31.6054
            14  C1x C    17.6493  -31.6231
            15  C1b C    19.8084  -29.5146
            16  C5a C    21.0206  -28.8139
            17  O5a O    21.0203  -27.4136
            18  N1b N    22.2335  -29.5137
            19  C1a C    22.2355  -26.7078
            20  C1a C    24.6533  -30.9072
            21  X   Cl   28.7396  -30.5199
            22  O0  O    33.2503  -29.1903
            23  C8y C    23.4457  -28.8068
            24  C8y C    23.4474  -27.4093
            25  C1a C    22.2355  -26.7078
            26  C8x C    24.6583  -26.7120
            27  C8x C    25.8677  -27.4122
            28  C8x C    25.8660  -28.8097
            29  C8y C    24.6550  -29.5069
            30  C1a C    24.6533  -30.9072
            31  N1b N    22.2335  -29.5137
            32  C5a C    21.0206  -28.8139
            33  C1b C    19.8084  -29.5146
            34  C1z C    19.8089  -30.9148
            35  N1y N    19.8148  -32.3137
            36  C1x C    21.1432  -32.7408
            37  C1x C    21.9626  -31.6054
            38  C1x C    21.1374  -30.4759
            39  C1x C    18.4804  -32.7525
            40  C1x C    17.6493  -31.6231
            41  C1x C    18.4745  -30.4817
            42  O5a O    21.0203  -27.4136
            43  X   Cl   28.7396  -30.5199
BOND        44
            1     6   1 1
            2     7   8 1
            3     7   9 1
            4     7  10 1
            5     8  11 1
            6     8  12 1
            7     9  13 1
            8    10  14 1
            9    11  13 1
            10   12  14 1
            11    8  15 1
            12   15  16 1
            13    1   2 2
            14   16  17 2
            15    2   3 1
            16   16  18 1
            17   18   1 1
            18    3   4 2
            19    6  19 1
            20    4   5 1
            21    2  20 1
            22    5   6 2
            23   24  23 1
            24   35  34 1
            25   35  36 1
            26   35  39 1
            27   34  38 1
            28   34  41 1
            29   36  37 1
            30   39  40 1
            31   38  37 1
            32   41  40 1
            33   34  33 1
            34   33  32 1
            35   23  29 2
            36   32  42 2
            37   29  28 1
            38   32  31 1
            39   31  23 1
            40   28  27 2
            41   24  25 1
            42   27  26 1
            43   29  30 1
            44   26  24 2
BRACKET     1    17.0100  -33.2500   17.0100  -25.4100
            1    30.1000  -25.4100   30.1000  -33.2500
            1  2
 ORIGINAL  1    1   6  19   5   4   3   2  20  18  16  15   8   7   9  13  11
            1   10  14  12  17  21
 REPEAT    1   23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38
            1   39  40  41  42  43

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