KEGG   DRUG: AranidipineHelp
Entry
D01562                      Drug                                   

Name
Aranidipine (JAN/INN);
Sapresta (TN)
Formula
C19H20N2O7
Exact mass
388.1271
Mol weight
388.3713
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
  DG01573  Calcium channel T type blocker
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
Activity
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01562  Aranidipine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Aranidipine
      D01562  Aranidipine (JAN/INN)
    calcium channel T type
     Aranidipine
      D01562  Aranidipine (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Aranidipine
    D01562  Aranidipine (JAN/INN)
Cardiovascular agents [br08364.html]
 Antihypertensives
  D01562
BRITE hierarchy
Other DBs
CAS: 
86780-90-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1y C    22.3513  -16.1389
            2   C8y C    22.3395  -18.5314
            3   C2y C    21.2049  -15.4862
            4   C2y C    23.4976  -15.4862
            5   C8y C    21.1874  -19.1958
            6   C8x C    23.4800  -19.1958
            7   C2y C    21.2049  -14.1634
            8   C7a C    20.0644  -16.1389
            9   C2y C    23.4976  -14.1634
            10  C7a C    24.6382  -16.1389
            11  C8x C    21.1874  -20.5067
            12  N2b N    20.0586  -18.5314 #+
            13  C8x C    23.4800  -20.5067
            14  N1x N    22.3513  -13.5050
            15  C1a C    20.0644  -13.5050
            16  O7a O    18.9240  -15.4862
            17  O6a O    20.0703  -17.3616
            18  C1a C    24.6382  -13.5050
            19  O7a O    25.7727  -15.4862
            20  O6a O    24.6382  -17.4615
            21  C8x C    22.3395  -21.1769
            22  O3a O    21.5634  -17.5379
            23  O3a O    18.1950  -19.7719 #-
            24  C1b C    17.7834  -16.1389
            25  C1a C    26.9133  -16.1389
            26  C5a C    16.6480  -15.4775
            27  C1a C    15.5075  -16.1302
            28  O5a O    16.6531  -14.1634
BOND        29
            1     1   4 1
            2     2   5 1
            3     2   6 2
            4     3   7 2
            5     3   8 1
            6     4   9 2
            7     4  10 1
            8     5  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12    7  15 1
            13    8  16 1
            14    8  17 2
            15    9  18 1
            16   10  19 1
            17   10  20 2
            18   11  21 1
            19   12  22 2
            20   12  23 1
            21   16  24 1
            22   19  25 1
            23    9  14 1
            24   13  21 2
            25   24  26 1
            26    1   2 1
            27   26  27 1
            28    1   3 1
            29   26  28 2

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