KEGG   DRUG: D01562Help
Entry
D01562                      Drug                                   

Name
Aranidipine (JAN/INN);
Sapresta (TN)
Formula
C19H20N2O7
Exact mass
388.1271
Mol weight
388.3713
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
Drug group: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01562  Aranidipine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Aranidipine
      D01562  Aranidipine (JAN/INN)
    calcium channel T type
     Aranidipine
      D01562  Aranidipine (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Aranidipine
    D01562  Aranidipine (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
86780-90-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1y C    22.3513  -16.1389
            2   C8y C    22.3395  -18.5314
            3   C2y C    21.2049  -15.4862
            4   C2y C    23.4976  -15.4862
            5   C8y C    21.1874  -19.1958
            6   C8x C    23.4800  -19.1958
            7   C2y C    21.2049  -14.1634
            8   C7a C    20.0644  -16.1389
            9   C2y C    23.4976  -14.1634
            10  C7a C    24.6382  -16.1389
            11  C8x C    21.1874  -20.5067
            12  N2b N    20.0586  -18.5314 #+
            13  C8x C    23.4800  -20.5067
            14  N1x N    22.3513  -13.5050
            15  C1a C    20.0644  -13.5050
            16  O7a O    18.9240  -15.4862
            17  O6a O    20.0703  -17.3616
            18  C1a C    24.6382  -13.5050
            19  O7a O    25.7727  -15.4862
            20  O6a O    24.6382  -17.4615
            21  C8x C    22.3395  -21.1769
            22  O3a O    21.5634  -17.5379
            23  O3a O    18.1950  -19.7719 #-
            24  C1b C    17.7834  -16.1389
            25  C1a C    26.9133  -16.1389
            26  C5a C    16.6480  -15.4775
            27  C1a C    15.5075  -16.1302
            28  O5a O    16.6531  -14.1634
BOND        29
            1     1   4 1
            2     2   5 1
            3     2   6 2
            4     3   7 2
            5     3   8 1
            6     4   9 2
            7     4  10 1
            8     5  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12    7  15 1
            13    8  16 1
            14    8  17 2
            15    9  18 1
            16   10  19 1
            17   10  20 2
            18   11  21 1
            19   12  22 2
            20   12  23 1
            21   16  24 1
            22   19  25 1
            23    9  14 1
            24   13  21 2
            25   24  26 1
            26    1   2 1
            27   26  27 1
            28    1   3 1
            29   26  28 2

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