KEGG   DRUG: D01593Help
Entry
D01593                      Drug                                   

Name
Nimetazepam (JAN/INN);
Erimin (TN)
Formula
C16H13N3O3
Exact mass
295.0957
Mol weight
295.2927
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anxiolytic
Remark
Therapeutic category: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01593  Nimetazepam (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Nimetazepam
      D01593  Nimetazepam (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
2011-67-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C2y C    15.6734  -10.8594
            2   C8y C    14.8313   -9.7498
            3   C8y C    15.1665   -8.3930
            4   N1y N    16.4275   -7.8149
            5   N2x N    17.0792  -10.8846
            6   C5x C    17.6811   -8.4372
            7   C1x C    17.9676   -9.8059
            8   C8x C    14.1594   -7.4246
            9   C8x C    12.8174   -7.8127
            10  C8y C    12.4822   -9.1695
            11  C8x C    13.4893  -10.1376
            12  O5x O    18.7252   -7.5028
            13  N2b N    11.1174   -9.5639 #+
            14  C8y C    15.0389  -12.1091
            15  C8x C    13.6373  -12.1091
            16  C8x C    12.9373  -13.3216
            17  C8x C    13.6373  -14.5340
            18  C8x C    15.0389  -14.5340
            19  C8x C    15.7389  -13.3216
            20  C1a C    16.4492   -6.4400
            21  O3a O    11.1174  -10.9639
            22  O3a O    10.0189   -8.7383 #-
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   14  19 2
            22    4  20 1
            23   13  21 2
            24   13  22 1

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