KEGG   DRUG: D01624Help
Entry
D01624                      Drug                                   

Name
Sarpogrelate hydrochloride (JP16);
Anplag (TN)
Formula
C24H31NO6. HCl
Exact mass
465.1918
Mol weight
465.967
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticoagulant, platelet aggregation inhibitor
Remark
Therapeutic category: 
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antithrombosis agents
Serotonin receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D01624  Sarpogrelate hydrochloride (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT2A-receptor
     Sarpogrelate
      D01624  Sarpogrelate hydrochloride (JP16)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Sarpogrelate
    D01624  Sarpogrelate hydrochloride (JP16)
  CYP2C9
   Sarpogrelate
    D01624  Sarpogrelate hydrochloride (JP16)
  CYP2C19
   Sarpogrelate
    D01624  Sarpogrelate hydrochloride (JP16)
  CYP2D6
   Sarpogrelate
    D01624  Sarpogrelate hydrochloride (JP16)
  CYP3A4
   Sarpogrelate
    D01624  Sarpogrelate hydrochloride (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01624  Sarpogrelate hydrochloride
  D01624  Sarpogrelate hydrochloride fine granules
  D01624  Sarpogrelate hydrochloride tablets
Phytochemicals used as drugs [BR:br08306]
 Phenylpropanoids and related compounds
  Stilbenoids
   Bibenzyls
    D01624  Sarpogrelate hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
135159-51-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8y C    20.8521  -17.4758
            2   O2a O    22.0660  -16.7720
            3   C8x C    19.6381  -16.7780
            4   C8y C    20.8521  -18.8773
            5   C1b C    23.2740  -17.4758
            6   C8x C    18.4301  -17.4758
            7   C8x C    19.6441  -19.5753
            8   C1c C    24.4879  -16.7720
            9   C8x C    18.4301  -18.8773
            10  O7a O    25.7019  -17.4758
            11  C1b C    24.4879  -15.3705
            12  C7a C    26.9100  -16.7720
            13  C1b C    28.1240  -17.4758
            14  C1b C    29.3380  -16.7720
            15  C6a C    30.5460  -17.4758
            16  O6a O    31.7599  -16.7720
            17  O6a O    26.9087  -15.3689
            18  O6a O    30.5446  -18.8789
            19  C1b C    22.0614  -19.5687
            20  C1b C    23.2732  -18.8671
            21  C8y C    24.4848  -19.5615
            22  C8x C    24.4893  -20.9581
            23  C8x C    25.7010  -21.6527
            24  C8x C    26.9083  -20.9505
            25  C8y C    26.9039  -19.5539
            26  C8x C    25.6922  -18.8595
            27  O2a O    28.1167  -18.8484
            28  C1a C    29.3341  -19.5460
            29  N1c N    23.2730  -14.6689
            30  C1a C    23.2730  -13.2659
            31  C1a C    22.0579  -15.3705
            32  X   Cl   33.1159  -19.4624
BOND        32
            1    15  16 1
            2     7   9 1
            3    12  17 2
            4    15  18 2
            5     1   2 1
            6     4  19 1
            7     1   3 2
            8    19  20 1
            9     1   4 1
            10   20  21 1
            11    2   5 1
            12    3   6 1
            13    4   7 2
            14    5   8 1
            15    6   9 2
            16   21  22 2
            17   22  23 1
            18   23  24 2
            19   24  25 1
            20   25  26 2
            21   26  21 1
            22    8  10 1
            23   25  27 1
            24    8  11 1
            25   27  28 1
            26   10  12 1
            27   11  29 1
            28   12  13 1
            29   29  30 1
            30   13  14 1
            31   29  31 1
            32   14  15 1

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