KEGG   DRUG: D01636Help
Entry
D01636                      Drug                                   

Name
Midecamycin acetate (JP16);
Miocamycin;
Miocamycin (TN)
Formula
C45H71NO17
Exact mass
897.4722
Mol weight
898.0417
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA11 Miocamycin
      D01636  Midecamycin acetate (JP16); Miocamycin
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Midecamycin [ATC:J01FA03]
      D01636  Midecamycin acetate (JP16)
BRITE hierarchy
Other DBs
CAS: 
55881-07-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        63
            1   C1y C    33.8994  -22.3801
            2   C1y C    34.9964  -23.0218
            3   O2a O    32.8069  -23.0218
            4   C1y C    33.8994  -21.1198
            5   C1y C    36.1054  -22.3801
            6   N1c N    34.9964  -24.2888
            7   C1y C    31.7156  -23.6524
            8   O2x O    34.9964  -20.4892
            9   C1a C    32.8126  -20.4892
            10  C1y C    36.1054  -21.1198
            11  O1a O    37.2035  -23.0218
            12  C1a C    36.0942  -24.9183
            13  C1a C    33.9051  -24.9183
            14  C1x C    31.7156  -24.9127
            15  O2x O    30.6064  -23.0218
            16  O2a O    38.9933  -18.0687
            17  C1z C    30.6064  -25.5544
            18  C1y C    29.5094  -23.6524
            19  C1y C    35.5430  -14.6467
            20  C1y C    29.5094  -24.9127
            21  C1a C    29.7511  -26.7644
            22  O7a O    31.4965  -27.2021
            23  C1a C    28.4226  -23.0218
            24  C1y C    35.5374  -13.3463
            25  C1y C    34.4228  -15.3054
            26  O7a O    28.4226  -25.5544
            27  C1x C    34.4059  -12.7101
            28  C1b C    36.6231  -12.7044
            29  C1y C    34.4283  -16.6057
            30  O2a O    33.4591  -14.6803
            31  C1y C    34.4059  -11.4332
            32  C4a C    37.7268  -13.3296
            33  C1x C    33.2968  -17.2588
            34  O7a O    35.5319  -17.2353
            35  C1y C    33.2911  -10.8025
            36  C1a C    35.4973  -10.7970
            37  O4a O    38.8181  -12.6877
            38  C7x C    32.1482  -16.6226
            39  C2x C    32.1998  -11.4332
            40  O7a O    33.2911   -9.5431
            41  O7x O    31.0011  -17.2532
            42  O6a O    32.1482  -15.3557
            43  C2x C    32.1998  -12.7101
            44  C1y C    29.8696  -16.5655
            45  C2x C    31.0794  -13.3463
            46  C1x C    29.9229  -15.2259
            47  C1a C    28.7548  -17.1737
            48  C2x C    31.0625  -14.6299
            49  C1a C    33.4489  -13.4192
            50  C7a C    27.3298  -24.9344
            51  C1b C    26.2429  -25.5761
            52  O6a O    27.3172  -23.6794
            53  C1a C    25.1501  -24.9629
            54  C7a C    35.5895  -18.5662
            55  O6a O    36.6712  -19.2456
            56  C7a C    34.5353   -8.8249
            57  C1a C    35.7265   -9.5130
            58  O6a O    34.5356   -7.4202
            59  C7a C    32.8965  -27.2021
            60  O6a O    33.6096  -28.4368
            61  C1a C    33.5854  -26.0092
            62  C1b C    34.3646  -19.2787
            63  C1a C    33.1417  -18.5782
BOND        65
            1     5  11 1 #Down
            2     6  12 1
            3     6  13 1
            4     7  14 1
            5     7  15 1
            6    10  16 1 #Up
            7    14  17 1
            8    15  18 1
            9    19  16 1 #Down
            10   17  20 1
            11   17  21 1 #Down
            12   17  22 1 #Up
            13   18  23 1 #Down
            14   19  24 1
            15   19  25 1
            16   20  26 1 #Up
            17   24  27 1
            18   24  28 1 #Down
            19   25  29 1
            20   25  30 1 #Down
            21   27  31 1
            22   28  32 1
            23   29  33 1
            24   29  34 1 #Down
            25   31  35 1
            26   31  36 1 #Down
            27   32  37 2
            28   33  38 1
            29   35  39 1
            30   35  40 1 #Down
            31   38  41 1
            32   38  42 2
            33   39  43 2
            34   41  44 1
            35   43  45 1
            36   44  46 1
            37   44  47 1 #Down
            38   45  48 2
            39    8  10 1
            40   18  20 1
            41   46  48 1
            42   30  49 1
            43    1   2 1
            44   26  50 1
            45    1   3 1 #Down
            46   50  51 1
            47    1   4 1
            48   50  52 2
            49    2   5 1
            50   51  53 1
            51    2   6 1 #Up
            52    7   3 1 #Up
            53   34  54 1
            54    4   8 1
            55    4   9 1 #Up
            56   54  55 2
            57    5  10 1
            58   40  56 1
            59   56  57 1
            60   56  58 2
            61   22  59 1
            62   59  60 2
            63   59  61 1
            64   54  62 1
            65   62  63 1

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