KEGG   DRUG: D01655Help
Entry
D01655                      Drug                                   

Name
Adefovir pivoxil (JAN);
Adefovir dipivoxil (USAN);
Hepsera (TN)
Product
  Generic
Formula
C20H32N5O8P
Exact mass
501.1989
Mol weight
501.4705
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00412]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
prodrug, active substance: Adefovir [DR:D02768]
Target
RNA-directed DNA polymerase inhibitor
Metabolism
Transporter: SLC22A6 [HSA:9356], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF08 Adefovir dipivoxil
      D01655  Adefovir pivoxil (JAN); Adefovir dipivoxil (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Adefovir
    D01655  Adefovir pivoxil (JAN); Adefovir dipivoxil (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D01655  Adefovir pivoxil (JAN); Adefovir dipivoxil (USAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HBV agents
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs)
     Adefovir
      D01655  Adefovir pivoxil (JAN); Adefovir dipivoxil (USAN)
BRITE hierarchy
Other DBs
CAS: 
142340-99-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C8y C    29.9600  -16.0300
            2   C8y C    29.9600  -14.5600
            3   N4y N    28.6300  -16.4500
            4   N5x N    31.1500  -16.6600
            5   N5x N    28.6300  -14.1400
            6   C8y C    31.1500  -13.9300
            7   C8x C    27.7900  -15.3300
            8   C8x C    32.3400  -16.0300
            9   N5x N    32.3400  -14.5600
            10  N1a N    31.1500  -12.5300
            11  C1b C    28.6300  -17.8500
            12  C1b C    27.3700  -18.5500
            13  O2a O    26.1800  -17.8500
            14  C1b C    24.9200  -18.5500
            15  P1b P    23.7300  -17.8500
            16  O2b O    22.5400  -17.1500
            17  O2b O    23.0300  -19.0400
            18  O3b O    24.4300  -16.6600
            19  C1b C    22.5400  -15.7500
            20  O7a O    21.3500  -15.0500
            21  C7a C    20.1600  -15.7500
            22  C1d C    18.9700  -15.0500
            23  C1b C    23.0300  -20.4400
            24  O7a O    21.8092  -21.1430
            25  O6a O    20.1600  -17.1500
            26  C1a C    17.7800  -14.3500
            27  C1a C    19.6700  -13.7900
            28  C1a C    18.2700  -16.2400
            29  C7a C    20.6459  -20.4401
            30  C1d C    19.4251  -21.1431
            31  O6a O    20.6335  -19.0384
            32  C1a C    18.2043  -21.8461
            33  C1a C    20.1281  -22.3639
            34  C1a C    18.7221  -19.9223
BOND        35
            1     2   5 1
            2     2   6 1
            3     3   7 1
            4     4   8 2
            5     6   9 2
            6     5   7 2
            7     8   9 1
            8     1   2 2
            9     1   3 1
            10    1   4 1
            11    6  10 1
            12    3  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   15  17 1
            19   15  18 2
            20   16  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  23 1
            25   23  24 1
            26   21  25 2
            27   22  26 1
            28   22  27 1
            29   22  28 1
            30   24  29 1
            31   29  30 1
            32   29  31 2
            33   30  32 1
            34   30  33 1
            35   30  34 1

» Japanese version   » Back

DBGET integrated database retrieval system